Five Health Side Effects of Splenda (Sucralose)

Since coming to market, Splenda has faced mounting criticism. The product is made from the artificial sugar substitute sucralose and has many potential side effects. Though Splenda was approved by the FDA, there have been many warnings and appeals to the FDA from consumers to include a warning on Splenda packaging so that those people buying the product will be aware of the risks. Some of the side effects of Splenda include:

Abdominal Cramping

One of the most common complaints from Splenda is abdominal cramping, bloating and pain that often resembles a pulled muscle, foodborne illness or more serious gastronomical problems. It often takes awhile for most people to form a connection to something they ate with Splenda. But once they realize that is the culprit, people with this reaction are more diligent about checking labels and avoiding the sweetener altogether.


With symptoms ranging from mild headaches to migraines, Splenda has long been blamed for headaches in many people. For most people experiencing this symptom, the results begin within minutes of drinking a beverage or other product containing Splenda and can last for hours. For most people, the symptoms stop within 24 hours after Splenda is cut from their diet.

Mood Swings

Many people who eat Splenda regularly have suffered from immense mood swings, but have had a tough time putting the connection between the mood swings and Splenda together. Because many people using Splenda are dieting and trying to lose weight, they often attribute the mood swings to other influences. But once they cut Splenda from their diet, they realize that the mood swings are alleviated altogether.

Weight Gain

Though Splenda was developed as an alternative to sugar with fewer calories, for many Splenda has caused weight gain. Whether it is a combination of bloating, overindulgence, or a direct result of ingesting sucralose, many people have found that it is easier to lose weight when cutting out sweets altogether instead of just replacing the natural sugar with an artificial one.


There have been many reports of people experiencing chronic fatigue after consuming products made with sucralose. In most cases, this fatigue and overall sleepiness is alleviated within a day or two of ceasing to eat products made with Splenda. The fatigue has been characterized by many symptoms, ranging from an overall sleepiness, to an inability to concentrate or focus, to a tingling and weakness in the limbs for hours after eating something containing sucralose. 

With so many potential side effects, it is no wonder that many are leery about using Splenda. Everyone’s body is different though, and many people experience no symptoms. At any rate, it is a good idea to keep track of when you ingest Splenda to determine if some of the side effects you may be experiencing are from Splenda, and if so, cut it from your diet.



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