C75 - fatty acid synthase inhibitor (leading into a rant)

Posted by tarisaande on March 26th, 2010 |Filed Under Uncategorized |

Here is a link to an article about C75, a fatty acid synthase inhibitor. I have done a little work with this at my job, and am trying to learn a bit more about it

http://www.bentham.org/emi/samples/emi1-1/Di%E9guez.pdf

In the abstract, it notes that it decreases food intake and bodyweight in rodents, and suggests fatty acid synthesis as a target or treatment of obesity.

Well, duh, fatty acid synthesis IS a target for treating obesity, but really, the best way to target fatty acid synthesis in the real world is by not overeating, or something.

I think it is very important to understand the biology of healthy weight and obese bodies, but every time something like this comes up (via work-related interest, on the 3fc or spark forums) it further backs up my feelings that the only REAL treatment for obesity is BEHAVIORAL MODIFICATION. Just because the rats ate less doesn’t mean this sort of thing would work in humans. The rats weren’t over eating in the first place! They already listen to their internal signals, and this drug told them to eat less, and being rats, they listen.

There are no such signals in obese people. Stop. Don’t tell me about the exceptions. People that are obese eat too much. They know it. I know it. You know it. There are signals saying STOP and we don’t listen! THEY ARE ALREADY THERE AND WE DON’T LISTEN. THIS IS WHY DIET PILLS DON’T WORK. If you aren’t going to listen to signals that are already there, treating them with drugs that amplify the signals isn’t going to help!


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