Over the past decade of lifting, I've become well acquainted with the "off-again-on-again sores." Just to give you something to look forward to, days 2 and 3 after the second workout are usually the worst.
When I'm starting up again after a long break, I often through in a bit of very light cardio after my lifting workout, especially if it involves legs. Then light stretching. Light is the operative word; the goal here is not to improve cardiovascular health or flexibility, but to get the blood flowing to the muscles and jump start the process of repair.
This helps a bit. So do ibuprofin, and strong towel bars to get down & back up again. What helps the most, though, is knowing that it's temporary, and that it means you're doing something positive for your health.
Be strong,
Kim