I would suggest reading the sticky links here. One site not to miss is
http://www.stumptuous.com/cms/index.php
I know there can be preferences in how you work out but I actually think a full body workout can be more discouraging than concentrating on different muscle groups.
I always liked the 4 day rotation which you can work out different muscle groups:
Push - Chest and triceps
Pull - Back and biceps
Legs - Hamstrings and Quads
"Other" - Shoulders, abs, calves
You can look at various websites and see what mix of muscle groups would work best for you.
I would recommend doing 3 sets with the last set reaching failure and generally the first set being a warmup set. You can mix and match and increase sets as you like. These days, I usually do 5 sets but I've done between 3-5 depending on my workout routine. I wouldn't recommend trying to reach failure at less than 8 reps but I personally like reaching failure somewhere between 8 to 12 on my last set.
It may take a bit of tweaking to see what works best for you.