I've been on Biodentical Progesterone for about 2 years; day 14-28 of my cycle. I'm 42 and in Peri-menopuase. My MD did a Hormonal Saliva test which indicated I am Estrogen Dominant (off the chart) with negligible Progesterone. Significant increased risk of Breast Cancer with these high amounts of Estrogen. Initially took some experimentation but found 5 mg once a day made a big difference for me. PMS symptoms leveled right out, sleep was better, significant reduction in mood swings, and no more migraine headaches at that time of the month. Also big reduction in cravings for sugars and carbs which seem to be super intense for the 7 days prior to starting my cycle.
One of the great benefits of Progesterone is that is is associated with tranquility and is a central nervous system relaxant. It binds to the same receptors in the brain as Valium and has a soothing and relaxing effect.
The cost to have the cream compounded is about $7.50/cycle (I live in AB and my Health Care covers the cost) but even if I had to pay out of pocket I would.
There is a tremendous amount of research and information available on the web regarding biodentical hormone replacement. The sources I've found most helpful are the books by Dr. Chhristiane Northurp (Women's Bodies, Women's Wisdom, Mother-Daughter Wisdom and The Wisdom of Menopause. Another Internationally recognized authority on Natural Hormonal Replacement is Dr. John Lee
www.johnleemd.com, here you can find just about everything you would want to know and great tools to share with your Dr.
Good luck with your research.
Nads