I'm probably somewhere on the bipolar spectrum. Naturally, I have cyclothymia; a misdiagnosis and a prescription of an antidepressant temporarily kicked that up to full-on bipolar, at least dx-wise, about five years ago.
I was on Effexor, Lamictal, and Seroquel. I'm not sure whether I gained weight during this time or not--my pants size didn't really change, but I think I might've gained in other places, who knows?--but the entire thing made it hard for me to care enough to lose weight. When I was up--well, relatively; mostly, I was mixed--it was hard for me to really focus on losing weight. Everything else was way more appealing. When I was down, I just didn't give a crap. Additionally, in my case, Seroquel basically sapped my will to do anything. I didn't want to get up most days, let alone do something as difficult as stick to a plan.
What's helped me immensely, control-wise, is regulating my sleep schedule. As long as that stays on a fairly even keel, keeping to plan seems to be a cinch. If I sleep too much or too little, my mood slips one way or the other, and my willpower starts to seriously wane.
It's hard. Fortunately, there's this place for the hard parts.
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