Yes they've found reproductive and mutagenic effects in lab animals. Offspring of hamsters fed large amounts of stevia had fewer and smaller offspring, and in male rats stevia reduced sperm production and the size of seminal vesicles (which would tend to reduce fertility). I've also read that there is some indication that large amounts of stevia, may be linked to kidney or liver damage in humans (but this is not conclusive, just a preliminary study or investigation).
One thing to consider is that unlike "unnatural" products, no research os required before advocating and marketing herbal products (whether or not, it's ever been used historically by humans - if you find a weed in your garden, you can probably sell it). Also, stevia has been used as an herbal supplement for years, but never in the quantities that modern Americans tend to use sweeteners. Even water is harmful in excess.
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