My best advice is to count your calories, watch your refined carbs and eat the better, lower glycemic carbs, and exercise, exercise, exercise! Try everything, find kinds of exercise you love, and rotate. Keep your body moving, and keep the routines fresh so your body keeps guessing. If you are IR, you need to exercise more than the average chick. Not fair, but it's really not so bad once you find something you love.
Oh yeah - weight lifting has helped me. If you increase your muscle mass, your body will burn more calories. Keep your nose to the grindstone and you'll make it!