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Alli
I did and, however much they try to fight it, there are too many complaints about gallbladder problems. I was on Alli for about 6 months and lost some weight that I can attribute to it (but that was on top of my dieting anyway). Then I developed gallstones, like so many others taking Alli.
There are other unlovely side effects, like constant diarrhea-like, yellow poo (and not easy to control when).
I would love a magic diet pill but, from my research, there are none and those that do work will cause you other problems.