I never attempted running (outside of the mile in gym class which I always HATED!) till I was 26. During my first weight loss I was primarily swimming for cardio, but I injured my shoulder and had to figure something else out for a while and started the c25k. I didn't immediately love it, but really grew to enjoy the sense of accomplishment. I feel like I burned out on it after the second half-marathon and pretty much stopped running for 2.5 years. I guess I have a love/hate relationship with running.
Bigknitter, I have the same problem trying to run with food in me. Anything other than fruit or maybe a piece of toast needs at least 3-4 hours. Friday I tried running a little more than 2 hours after lunch, that didn't go well at all. It had a lot of fiber, so I guess it wasn't digesting very quickly.
I made it out for two pretty terrible and short runs this week. I had some really good runs on vacation the week before, but had a pretty rough week coming back, one of those things where it feels like nothing can go right. I ended up riding my bike to/from school 4 days this week (usually only do 2 or 3) so I was feeling a little fatigued from that and running on top of it just wasn't going well. Took a nice rest day today, only activity was a 1.7 mi stroll with the dogs. Digging into my mapmyrun.com archive and doing a 4.25 mi route tomorrow, first thing in the morning after some hydration and fruit.

I am really hoping this will be the one that sticks. mk, exciting is one way to put it! Between anxiously waiting to find out whether it worked and the hormone injections, I'm pretty much a basket case for two weeks! Btw, I'm sure the offspring will TOTALLY understand if you can't see them because you have to bike AND run. 

That's one of my "one day..." goals! 
I used to loathe running, and even when I started running regularly in September I can't say I really enjoyed it... I just enjoyed the feeling of accomplishment I felt from being able to do it. But I love it now!!
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I'd like to see me running that fast again one day, I'm sure a lot of that will come with weight loss. I was around 30 lbs lighter then.