I don't know the science behind it, but here's my take:
If you're working both sides equally, that won't balance out the fact that one side has been stronger for years. You'd have to really work the opposite side hard to see it come equal.
However, I'm a righty, and I know that I use my right hand for tons of stuff during the day that I don't even think about (e.g. opening a jar of pickles), so workout time aside, I'm always going to be strengthening my primary side.
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