I respect that you prefer a low-carb lifestyle, but to arbitrarily state that it is the superior option for all populations is misguided, IMO.
For one thing, losing weight comes from many different things: eating below your TDEE, losing water vapour during exhalation, voiding (either #1 or #2), changes in bone density, your body changing how it holds onto water, etc. But to lose weight in the sense that I think you mean, it has everything to do with a caloric deficit. Fat vs. carb doesn't even come into the discussion.
Yes, everyone will lose more WEIGHT initially with a low carb diet, specifically due to glycogen storage & water retention. That balances out pretty quickly though, within a month or two:
https://www.ncbi.nlm.nih.gov/pubmed/17415320
Those who display symptoms of insulin resistance do better with fewer carbs - no argument there. But in a healthy population, there is no statistical difference:
A Low-Glycemic Load Diet Facilitates Greater Weight Loss in Overweight Adults With High Insulin Secretion but Not in Overweight Adults With Low Insulin Secretion in the CALERIE Trial | Diabetes Care . And in those whom are insulin sensitive, they could actually lose more weight on a low fat diet:
https://www.ncbi.nlm.nih.gov/pubmed/15897479
Insulin and of itself isn't an issue - after all, we need insulin to preserve muscle mass too. Protein is also actually quite insulinogenic - it just doesn't raise blood sugar levels. The problems come in when there is insulin resistance in muscle cells, which most commonly correlates to high bodyfat percentages. Again, insulin doesn't cause fat gain - that's entirely dependent on if you are consuming a caloric surplus or not.
And in already obese subjects, overeating fat is more likely to cause fat storage than overeating carbs:
https://www.ncbi.nlm.nih.gov/pubmed/7598063
Ironically, there is even some postulation that too much fat itself causes insulin resistance as well:
https://www.ncbi.nlm.nih.gov/pubmed/16319806 And a low carb diet doesn't necessarily improve insulin resistance:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370345/
Those with Alzheimer's who follow a high fat diet show a slowing of cognitive decline, absolutely. But the only models that propose ketone metabolism in the brain shows protective conditions against future disease are all in rats & mice - which is to say, it hasn't been shown to have the same effect in humans. For some, a low fat diet may actually have a negative affect on moods long term - but there's no difference in cognitive function:
https://jamanetwork.com/journals/jam...rticle/1108558 . Ketones have also shown mixed results in terms of improving or inhibiting athletic performance. So it comes out even: no clear evidence that suggests that humans 'run better' on ketones.
Longer term low carb diets have shown to decrease T3 levels, a symptom of developing hypothyroidism -
https://www.ncbi.nlm.nih.gov/pubmed/28076316. It also results in lowered testosterone and increased cortisol - which makes you more likely to store belly fat and it's harder to build muscle:
https://academic.oup.com/jcem/articl...1/4480/2598960 . There is also some new data that suggests that long term ketogenic diets can affect the rigidity/shape of arterial wall - not great:
https://www.sciencedirect.com/scienc...59131113003397 Though I'll readily admit that more research needs to be done on this.
No, fat doesn't activate higher levels of leptin than carbohydrates:
https://www.ncbi.nlm.nih.gov/pubmed/10567012 &
https://www.ncbi.nlm.nih.gov/pubmed/12753550
Weight loss is generally similar across any caloric deficit long term:
https://www.ncbi.nlm.nih.gov/pubmed/19246357 &
https://jamanetwork.com/journals/jam...stract/2673150
On a side note, while RDA for protein is 0.8g/kg of bodyweight (0.36g/lb), newer studies suggest that if you are over 40 and sedentary that should be bumped to 1.2g/kg (0.55g/lb). For obese subjects trying to lose weight, even higher numbers (eg. 1.5g/kg, 0.68g/lb) are recommended. Pregnant women need at least double RDA, at 1.6-1.8g/kg (0.730.82g/lb). And non-obese subjects attempting to lose fat/weight should be aiming for 2.2-3.4g/kg (1-1.55g/lb) in order to preserve muscle mass. To gain muscle, the recommendations are similar to losing fat, with the suggestion that higher levels do not show any adverse affects on renal function or overall health - and may help prevent fat gain in a caloric surplus.
I think that if you do well with a low carb diet, that's great - keep with it! But it is not immediately the best choice for everyone under the sun. It all comes down to how you respond, and how you feel, with different macronutrient ratios. And what your Dr. says in terms of the results on long-term cardiovascular and endocrine health - on an individual basis.
We could trade cherry-picked studies back and forth all day, but I imagine we can agree that the best judge of which system is best comes down to how the individual responds.