I was never on SSRI's, the first antidepressant drug i ever tried was wellbutrin and i def have to recommend it. SSRI's are notorious for causing weight gain and because i was concerned about this I actually requested wellbutrin from my doc and didnt even give her a chance to suggest anything else. Part of the reason I went on it was for the help quitting smoking, although i went a full year after I started taking it to even try to quit (I was really afraid to give up that last cigarette ). When I did finally quit, on Jan 1, it was pretty easy, at least compared to all the times Ive quit smoking, and I am so impressed. I havent caved or even had a bad craving since I gave them up. Anyway, the wellbutrin works great for depression too, I've felt like my old self since Ive started it, not like "fake" happy, if you know what I mean, and it does give you the motivation to get up and do something, it gives you a lot of energy, especially initially, now that will eventually level out but I must say, if I get off track taking it and miss a couple doses, I can really feel it, I become an emotional wreck. Sorry this is turning into a book, lol. The point is, wellbutrin is an excellent drug, at least it is for me, and I wouldnt even be attempting this weight loss (for like to 50th time in my life, lol ). if I wasnt on it. One very important suggestion though, I started on the generic , which worked for a couple of months but then I started to feel really crappy and gain weight and was all blah. When I researched it, I found that most people dont do well on the generic, that it in fact is not at all anything like the brand name. So i decided to pay the extra 30 bucks a month for the real deal, and it is def a huge difference. If your doc or insurance co will will help you out, I would ask for a "brand name only" script if you decide to try it. Good luck, I hope everything works out for you.