I tried Wellbutrin about 5 years ago as a migraine preventative (didn't help), and about 2 weeks after starting it I had a massive attack of hives. I read online at the time that this was relatively common, and a lot of people who experienced it had it go away in a short amount of time. Still, my neurologist discontinued the drug.
However, dealing with depression has been interfering more and more with my progress in school (graduate student) so this October I asked my doctor to put me on antidepressants, and specifically Wellbutrin because of it's decreased frequency of being associated with weight gain relative to pretty much every other antidepressant. And luckily, I've been taking it for almost 3 months now, and not a single hint of hives or anything like that, and I've been feeling better.
Although also, it seemed like a lot of women do experience menstrual changes on Wellbutrin... so I think it's likely my own recent issues (spotting for the first time ever, longer time between periods) may also be related to the Wellbutrin.
It's been a little bit now since your original post, so I'm curious; did you decide to stick with the Wellbutrin? Have your hives etc resolved at all?
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