We were told after my father had his stroke that the massive quantities of aspartame he was consuming led to a drastic reduction in his thiamine levels and contributed to his problems. Granted he was drinking 4 or more litres a day. I went to full sugar regular coke after that, and drank way too much of it. I gave up the pop even before I started to diet. Now I have the occasional one as mix for an alcoholic drink, or the occasional can of cherry coke, but I find about half way through it I feel ill.