Like Rachel, I started around 250. I took it very slow, and I mixed walking with jogging until I could just jog (since then, I haven't looked back -- it bores me to walk). Rachel has finished a marathon, I've finished a half marathon, I'm now a running coach and I'm preparing to run a marathon next year. So if we could do all that after starting at 250 -- you'll be fine!
Some advice (besides the great advice about shoes and consulting a doctor and all that everyone else has said):
*Your knees might hurt at first. Mine did, and I iced them at night after my runs. I put my legs up and iced them for about 15 to 20 minutes, and I was fine. It didn't take long for the pain to go away, partly because my body was getting used to running and also because I simply started weighing less.
*Do NOT worry about speed. Not in the beginning. Not for a LONG time. Too many people start out thinking they have to sprint, and then they HATE running. Go as slow as you want to go -- if you're propelling yourself off the ground a little, you're running. You'll get faster naturally with time. When I started it took me at least 13 minutes to run a mile (that's after working up to the point that I could run for that long). Now I usually run at a pace around 10 minutes a mile or faster, depending on the length of the run. I'm still not speedy, but I've made improvement. You will too, and it will happen naturally.
*When you can run a few miles without stopping, sign up for a 5K. Don't worry about your time -- just go and finish a race, even if you walk part of it. You'll have fun, and then you'll sign up for another one. A cycle will begin, and you'll HAVE to keep running because you'll always have a race coming up! And did I mention that races are fun?
I'm sure I have other advice (as everyone knows, I won't really shut up about running now that I've fallen in love with it), but for now I'll stop rambling!
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