I started out on Ortho Tri Cyclin Lo, and was on it for years. I loved it, but they came out with the generic version and that caused harsh acne for me, and I am not one to have acne at all really. I was switched to Desogen and it literally made me feel like I was going insane. Paranoid, the works. It was bad. I was then switched to the generic form of Yasmin, which they suggested because of the PCOS and I have had no issues on it. I think it is important to realize that there are going to be horrors for different individuals for everything. Just the way it is, but by trial and error you will find one that works for you