It depends on what you're using it for: Generic cardiac health, lowering your triglyceride levels, serotonin boosting (depression, anxiety, mood elevation, pain relief), or inflammation (and other uses - it may for example reduce the nausea of cancer treatment - the jury's still out on that one).
My doctor says he usually recommends 1,000 to 2,000 mg for general, cardiac health. The bottle directions on the brand I buy recommend 3,000 mg. One 1,000 mg capsule at each meal (I do not doubt that it's a safe dose, but they're also trying to get you to use up their product faster so you buy more, so I don't know that it's the best dose).
Even higher doses can be prescribed for triglyceride-lowering effects and to reduce NSAID (drugs to treat inflammation without steroids like ibuprofen, naproxen, relafen, Celebrex) use in patients with rheumatoid arthritis and other inflammatory conditions.
I personally take about 4,000 mg or more, divided in 2 or 3 doses, but it's because I'm using it under my doctor's supervision to replace the prescription relafen I was on before (we discovered that I can't take NSAIDs, because they were causing me severe asthma and other respiratory problems).
Unless you have any health issues that would justify a larger dose 1,000 mg is probably the place to start (and before taking more than 3,000 mg talk to your doctor).
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