I have been on four different types of anti-depressants over the last 10 years. Some definitely worked better than others and some have fewer side effects. As the medical community is quite aware different drugs work better for different people they readily admit that they are trying the one they think is best but that they don’t really know until you’re on it.
Right now is the best I have ever felt and I’m on a combination of Wellbutrin and Celexa.
I do believe you also need to work with other methods to get as close to a full healing as possible. I have been working with a psychologist on ‘Cognitive Behaviour Therapy’, which seems to give me a better insight as to my thoughts during a depressive episode.
It is a very slow process for any type of improvement and the drugs, as Nova said, take at least a month to give any relief. It’s a long hard road.