My husband has very bad diabetic neuropathy (nerve pain and numbness) in his legs and feet, and has numbness in his hands too. He also has a disk problem that is causing him severe back pain, so he is on a whole cocktail of meds, including pain meds. For pain, he is taking darvocet, cymbalta, lyrica, relafen, and tramadol. Until the doctor added tramadol and switched relafen for the naproxen he had been taking, nothing was really helping enough to provide much relief. He had been on tramadol alone (before the darvocet) and it didn't help at all, but taking it now with all of the other meds, boosts the pain relief enough (finally) that he is getting some relief.
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