You bet! In fact, getting started on a run for me is the hardest part. The first few minutes are hard, mainly because I'm not warmed up. But once I've been going for a while, it gets easier, and I virtually always finish up feeling much stronger than when I started out.
The first thing is - are you trying to go too fast? You should monitor your breathing and heart rate. If your heart rate is high and you're panting, then slow down, and you'll be able to sustain the pace longer. If your heart rate and breathing is OK, then it's a psycological barrier.
One mind trick I use is to tell myself that I'm just going to start and see how I feel. I don't think about how far or long I'm going. Just promise myself I'll do the first xx minutes (or miles) and that's it. But once I get there, I find I can keep going.
Another thing you can try is varying your speed. If you start out at your normal speed and get warmed up, then toss in an interval at a faster speed (say, 30 seconds, or a minute), then back off to your normal speed ... suddenly your normal speed will seem MUCH easier.
And ... so what if you do walk? If calorie burn is what you're after, and walking breaks help you to go farther and longer, then there's no shame in that. Plenty of people use structured walk breaks as a strategy for distance running. You can PLAN your walk breaks, and then it's not a failure, it's a training plan. Such as: run 3 minutes, walk 1, repeat. Or whatever works for you.
Hope that helps!
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