I'd have to say that I don't personally think any pill or supplement will work...Cortislim or whathaveya. Because the principal they work on is boosting metabolism or curbing appetite. Well everyone's metabolism is different. So it might boost one person and not another. An aside regarding this "double blind" study. Losing 10 pounds as a group is not a miracle. The whole 10 pounds could have been one individual more motivated to lose than anyone else. But they never give that kind of information for some reason.
The other reason they don't work is that they are not a lifetime choice. Can they help one person with the right metabolism to lose weight? Yes. Will that person keep it off? Most likely not. Unless they're committed to taking the supplement for life, they will still be eating and getting the same amount of exercise as they'd always done before taking the supplement.