This is definitely a personal choice issue and you will find many of us have different opinions. I don't ever use asparatame and rarely use splenda. On the other hand I don't much care for the taste of stevia, but my diabetic partner uses it frequently. When I use sweeteners I either use agave or erythrytol. I could give you my list of reasons but, as I said, everyone has their own take on this. My recommendation is to do some research. Watch the sites because there is a lot of nutty info out there about this topic, but there is also some good information. Figure out what matters to you and then make sure the taste works too. good luck