Speaking personally, I can tell a difference if I've laid off for a few days or a week. The first session or two is definitely harder. But if the layoff was short, then I find the fitness level bounces back quickly, within a few days. If I've been training really hard, sometimes the rest period is actually beneficial and I end up coming back stronger than before. If you have to lay off for weeks, then that's a different story.
If you are sick, it's important to get over that first! Once you start feeling better, easy back in slowly. Then ramp the intensity up. You'll be right back in the groove before you know it.
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