Echobaby, not a clue on the O3 for depression. I would think you have to take a considerable amount. I've been eating fish a lot now that on the diet....not sure if that is enough O3 to affect bipolar depression...I'm not depessed....maybe...
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"The 1999 Harvard pilot study that started it all was conducted on 30 patients with bipolar disorder, generally in stable condition but with a history of relapses (all had experienced bipolar episodes over the past year). All but eight of the subjects were on medications, which were left unchanged. Half the subjects were given 9.6 grams of fish oil capsules, the other half received olive oil.
Andrew Stoll MD, who conducted the study, admits the olive oil, which did not have a fishy taste, was not a perfect placebo. In one case, a person's cat actually attacked the fish oil capsules. But, as he jokingly confessed in a session at the 2000 DBSA annual conference, "you want a flawed study. That way, you get money to do another study."
The trial was supposed to go on for nine months, but was stopped after four due to its outstanding results, with the omega-3 group staying in remission significantly longer than the placebo patients. By two months, half of the placebo group had dropped out compared to two in the fish oil group. The omega-3 group actually did less well in lowering their mania scores than those taking placebos, but fared much better getting their depression down. Some patients experienced nausea, diarrhea, and fishy aftertaste, not surprising considering the high doses."