Hmmm I just posted about Splenda (and artificial sweeteners in general) in the Acomplia thread, but I'll repost what I wrote here:
Splenda, asparatame and saccharin have been studied and researched for years (saccharin has actually been around for well over 100 years and has a great safety record!) and I personally believe they are safe and can be used with no problems for the vast majority of the general public. Of course there is always going to be a segment of the population who will have an adverse reaction to Splenda or asparatame, just as there are people who have adverse reactions to MSG, dairy products, wheat, peanuts, etc. I know that you've probably seen the anti-sweetener websites (one even run by the Sugar Institute - can't take the competition I guess!) but it is important to realize that the organizations behind them very much have their own agendas at play.
You can go to pubmed.com and browse through the published, peer-reviewed studies on pretty much anything...here's one
abstract for example...
Quote:
Ann Oncol. 2004 Oct;15(10):1460-5.
Artificial sweeteners--do they bear a carcinogenic risk?
Weihrauch MR, Diehl V.
Department of Internal Medicine I of the University of Cologne, Cologne, Germany. [email protected]
Artificial sweeteners are added to a wide variety of food, drinks, drugs and hygiene products. Since their introduction, the mass media have reported about potential cancer risks, which has contributed to undermine the public's sense of security. It can be assumed that every citizen of Western countries uses artificial sweeteners, knowingly or not. A cancer-inducing activity of one of these substances would mean a health risk to an entire population. We performed several PubMed searches of the National Library of Medicine for articles in English about artificial sweeteners. These articles included 'first generation' sweeteners such as saccharin, cyclamate and aspartame, as well as 'new generation' sweeteners such as acesulfame-K, sucralose, alitame and neotame. Epidemiological studies in humans did not find the bladder cancer-inducing effects of saccharin and cyclamate that had been reported from animal studies in rats. Despite some rather unscientific assumptions, there is no evidence that aspartame is carcinogenic. Case-control studies showed an elevated relative risk of 1.3 for heavy artificial sweetener use (no specific substances specified) of >1.7 g/day. For new generation sweeteners, it is too early to establish any epidemiological evidence about possible carcinogenic risks. As many artificial sweeteners are combined in today's products, the carcinogenic risk of a single substance is difficult to assess. However, according to the current literature, the possible risk of artificial sweeteners to induce cancer seems to be negligible.
Here's another...
Quote:
Med Pregl. 2003;56 Suppl 1:27-9. Related Articles, Links
[Controversies with aspartame]
[Article in Serbian]
Jankovic SM.
[email protected]
INTRODUCTION: Artificial sweeteners are nowadays inevitable food additives, since they provide necessary food diversity to people suffering from diabetes. Aspartame is the most frequently used artificial sweetener ever and its safety profile is much better than that of saccharin or cyclamate. It received marketing approval in 1973, but only 3 months later aspartame was withdrawn because of allegations based on improperly designed experimental studies dealing with its carcinogen effects on rodent brain. However, extensive studies using the same model did not confirm such suspicions, and aspartame received a second marketing approval.
EPIDEMIOLOGICAL STUDIES: Almost two decades later an epidemiological study found a relationship between aspartame and an increased frequency of brain tumors in humans. However, this study included a short time span of observation, and it did not estimate actual intake of aspartame, which led to loss of validity. Later on no epidemiological studies found correlation between aspartame use and incidence of brain tumors in humans. Up to now the only safety concern about aspartame, which received valid scientific proofs, is pro-seizure action of its excessive intake. In patients with epilepsy, excessive intake of aspartame can decrease the threshold for seizures or prolong them once they appear. However, if the intake is not above the recommended level of 40 mg/kg b.w./day, aspartame is well tolerated even in this subpopulation. CONCLUSION: Based on detailed analysis of published studies on safety of aspartame, it should not be restricted, but used in recommended amounts.
and some more studies can be found here...
IMO - the bottom line for any kind of drug or food or whatever comes up to this - if you don't want to use it, then you don't have to...it's a personal choice. Personally I would say that the people going after artificial sweeteners should shift their efforts towards tobacco, trans fats, and high-fructose corn syrup instead - they're FAR more harmful to the general population!
******
It's been awhile since I've mentioned this so for the benefit of those who don't know, my father was a food chemist for 40 years. Specifically he formulated soft drinks, specializing in DIET soft drinks for the most part. Growing up, my sisters and I got to drink a LOT more soda pop than the other kids in our neighborhood, since we had a garage full of it (99% of the time it was diet pop, mostly 'testers' - flavors/formulations that were being tested). Dad started working with aspartame back in the mid-1970s, so the four of us girls (plus mom, dad, and our friends) got to start consuming aspartame earlier than most of the general public (it didn't really start coming out in stores until around 1981 or so). Besides the soda pop, we also had a HUGE bag - like trash-can size - of NutraSweet gumballs (needless to say we were very popular around the neighborhood!) for awhile.
Dad doesn't spend a lot of time on the 'net - he's in his 70s now - but he could not BELIEVE the hubbub being made about Aspartame (and besides being a chemist, he also has a medical degree from a prominent East Coast university and practiced medicine in the armed forces). Basically he said that if he had thought that there was ANYTHING harmful about Aspartame or for that matter, ANY ingredient he worked with, that there was NO WAY he would bring it home for us girls and POISON us. And apparently it did no harm - I've been using the stuff for about 30 years now and have had no ill effects (none of my 3 sisters has had weight problems BTW).
So there's my 18 cents or so.
