I don't know about it's interaction with IR and PCOS, but I can tell you that Alesse (well, I use the generic of it) was the only birth control pill that I never had any adverse side effects from. I've been taking it for 3 years. Everyone is different, but I went through 5 pill prescriptions that made me VERY crazy before I finally got Alesse, and it has never cause me any ill side effects. I hope it works for you as well.
