There are big differences between running outdoors, on the treadmill and on the spot... Outdoors you have all the resistances, hills, wind, etc., on the treadmill, you have the machine propelling you, on the spot, as Ashley said «... you are running in place you land on your toes, with your leg straight below you putting pressure on your knee as well.» BUT doing something is better than doing nothing... If it gives you sore knees, run around the living room, pool table or your significant other
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