I used to take Premarin, but switched to Estroderm patches. The Premarin gave me a lot of side effects. I don't think weight was one of them, since I was only on it for a short time. Estroderm is completely different from Premarin, so if your body is not tolerating it, a switch might help.
The best thing about Estroderm patches for me, is that I don't have to forget to take a pill. I change the patch twice weekly.
Good luck
