I have an endocrine disorder that resembles PCOS. I have elevated testosterone, elevated cortisol, high normal insulin, and digestive hormones that don't work. I was put on metaformin but it made me very sick. I'm also on Alesse, which is very similar to ortho tricyclin lo... it is a low dose estrogen pill. And, I take aldactone, which is also called spironolactone.
All of the medications can make you nauseated; especially the metaformin. Some of the birth control pills can cause gall bladder issues. Spironolactone can make you dizzy. I take all of my meds at night because that is easier for me to remember to take them with dinner, and because the spironolactone makes me dizzy.
I'm apparently very sensitive to most medications: if there is a side-effect listed, I'm probably going to have at least one.