With some people, "no thank you" will not do, but I find it important not to be confrontatinal.
"No, I don`t need that" would probably verge on insulting me if I was the person who offered something. It`s not like they want to poison you (well, most of the time).
What often helps me is "not now, thanks". It implies that, in principle, I`d enjoy it but just now, I really am not hungry.
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