Acomplia - now THIS sounds interesting!!
 

Now everyone knows I'm a COMPLETE skeptic, but ya know I'll be watching how THIS develops:

Wait and see...note that the article does say the drug would have to be taken indefinitely - kind of like a birth control pill. IF IT IS SAFE AND EFFECTIVE, shoot - I wouldn't mind taking a pill every day to help lose and maintain a healthy weight! Of course, that doesn't mean I wouldn't be watching my nutrition and exercise...

I saw that on the news yesterday!! I'm curious to hear more about it once it is actually out on the market.

Well, think logically about that, if you are taking the pill to help lose weight, odds are your subconcious is going to kick in and you are going to be doing things you wouldn't normally do to:

A: Make the process go even faster

and

B: Keep the weight off.

Kind of like when you get something new and kind of expensive, you coddle it for a while so it won't get broken without even realizing it. Many people do this, it's normal. Odds are while you're taking the drug, you're lifestyle would change to the point that if you went off the pill and gained a few pounds, it wouldn't matter, because with your new lifestyle you'd lose them again anyway. The reason they gained weight after going off the pill was probably because this was a controlled study, and they told the participants not to do anything out of the ordinary (AKA: eat differently or exercise more than they were doing).

Guess we'll see what transpires. From what I've read, there has been EXTENSIVE testing and study on this drug already (I'd think that the pharmeceutical companies are being extremely cautious after the Redux/Phen-Fen debacle of the 1990's). I've found a report of one of the studies - this is the 2-year North American study of the drug, known as Acomplia.

Note that the people that gained weight after going off the pill in the second year were on a placebo - they didn't know that they were off the pill. Additionally, all participants were on a reduced-calorie diet throughout the study.

As much as I think some day there will be a miracle pill, it makes you wonder. Look at all of these drugs and what they do to people. I love listening to these commercials and wondering why people even bother. Eye drops for dry eyes that can cause temporary blindness and burning. A feminine product that can cause dementia and heart attack. Heck, just look at what the research is saying high fructose corn syrup does to us. (Maybe I should cut back on the splenda!)

I guess my point is even though it takes a lot of work, I'd rather watch what I eat and exercise than take a pill which will lower heath risks of being overweight only to cause a side effect of paralysis or something.

I've read quite a bit now about Acomplia, and the way it works is NOT to 'lower health risks of being overweight' - what it's supposed to do is reduce or eliminate CRAVINGS for food - that dreaded HEAD HUNGER which is, IMO, the main reason 'diets don't work' for so many, and the bottom-line reason for our obesity epidemic. Many, many, MANY times in the past, I've eaten - or overeaten - not because I was hungry, but because the food was there and I was/am addicted to the taste. Of course, if this drug (as well as the promising-sounding Hoodia plant - see the sticky thread in this forum) works like it's supposed to, its function is NOT to 'melt off fat' or 'burn fat' - you STILL need to do the work of eating right and exercising, making those healthy, permanent lifestyle changes...however, taking a SAFE and EFFECTIVE drug to reduce/eliminate cravings for food (or smoking, or drug/alcohol abuse) would help tremendously. :yes: I wholeheartedly believe that sugar and fat are as addicting as tobacco, alcohol or drugs, and YUP - if there was a safe and effective pill available to help with those cravings that can be taken on a long-term basis, I would most definitely ask my doctor about it, because even though it's been 15 years since I was obese, those cravings can really do a number on me...

The spectre of Phen-Fen is always in the background...IMO, as previously stated, I believe that the pharmecutical industry learnt a valuable (and costly) lesson from that experience and will be VERY careful about both short-term and long-term safety.

But I already take a BCP and a multivitamin every day anyway. I know quite a few people on daily meds - HRT, blood pressure, heart meds, etc. To be able to take a daily medication to allieviate those killer cravings...I wouldn't have a problem with that whatsoever, as long as it's SAFE AND EFFECTIVE. We'll see what happens...

This is all very interesting. I have read very little about this drug but it does show some promises. I am so afraid of medications now I doubt I would take it. I took Celebrex and now you read all this terrible stuff about it. And the weight gain was terrible. Who knew? It would be so nice to have a pill to take but realistically I'm sticking to my calorie counting. :^:

I think the best thing to do it stay away from drugs to loss weight. I took phen-fen when i was 15 years old. By the time i was 17 teen i started passing out. My heart was damaged and know ever six months i have to have my heart checked to make sure theres no bleeding. I still pass out time to time. Dr. still try to give me diet pills but i want take any to scared.

Hi there. Just thought I'd drop a note on this subject. My best friend was/is actually doing the testing for this drug. She works for Sanofi in Pennsylvania. From what she says and has seen, it works. It should become available in or around May 2005. They've had extremely successful results with this drug and are very excited to be offering it soon. If I hear more from her, I'll post again and give an update. All I know is that I'll be buying some stocks in Sanofi soon. Lol. :lol:

That's interesting!

However...3 months sounds a bit soon for a prescription drug to be put on the market. The most recent information I could find says that Sanofi is still doing clinical trials on the drug - doesn't look like it's even gotten to the FDA yet. And with the recent news regarding other prescription drugs such as Vioxx and in the past with Redux and fenfluramine, I'm sure that the FDA will be very, VERY careful in reviewing Acomplia.

Perhaps you meant 2006?

That may be true - and if you look at many of my previous posts, you'll know that I'm one of the all-time biggest skeptics as well as a fervent advocate for 'eat less/move more' (after all, that's how I lost AND how I've kept off 115 pounds over the past 15+ years). However...I think that there IS a definite need for a truly SAFE and EFFECTIVE (emphasis on SAFE) pharmeceutical weight loss aid for a variety of reasons - just off the top of my head:

* The HUGE increase in weight loss surgeries - which is supposed to be utilized as a last resort after everything else (regular diet and exercise) has failed, to me is a PRIME reason to be looking for other medical alternatives. Often it is not covered by insurance (and more and more carriers or employers are declining to cover the surgery) and it's a fairly risky procedure, with a very high price tag. IMO having a viable pharmecutical alternative to WLS would definitely be a plus.

* I remember back in the 1970's & 80's there were TONS of 'miracle hair restorer' products on the market...maybe as many or MORE than there were 'miracle weight loss' products. Then in 1988, Rogaine became the first pharmaceutical ever approved by the US Food and Drug Administration as being safe and effective for hair growth (followed in 1998 by Propecia) and the VAST majority of those 'miracle hair cures' went POOF. I can easily see that happening in the event that a truly safe and effective weight loss medication (I would rather not use the term "Magic pill") is found. If Acomplia turns out to be 'what the doctor ordered'...IMO that would be a fatal, or near-fatal, blow to many of the weight loss snake-oil hucksters out there.

(BTW I can't resist adding that when I typed the bit about hair loss, I couldn't help but visualize that Seinfeld episode where George orders the stinky hair growth potion from China... :lol: )

And if it helps smokers quit - there's ANOTHER bonus. :)

Of course bottom line it comes down to 'calories in calories out'/'eat less move more' - but there are MANY people who need help - I suppose, like WLS, you would call it a 'tool'.

I work in a large med. school where the Pharm. Reps. round constantly. The next time I see the Sanofi-Aventis rep. I'll ask her for some info. on approval. marketing dates. This may become popular from a cardiovascular point of view. Since Sanofi bought out Aventis I haven't seen too many of the old pharmaceutical reps, they usually shift things around.

what caught my eye was the line about "reduction in weight circumference" (I'll beg for samples of the drug if that is true!)

In my area, on one of the local cable stations, one of the bariatric surgeons actually has an infomercial......

We've all seen what can happen to a drug touted as the miracle answer, whether it's for weightloss, arthritis, diabetes, etc. Researchers find something that truly does work, but they can't know the safety record until millions of people have volunteered to be guinea pigs for them.

All drugs are poison, in some form or another. Each of us reacts differently to the poison--some of us would take Vioxx today if we could get our hands on it, because it did NOT cause us health problems. But it was deadly for others, and we only found out too late.

I'd love to think that modern medicine could come up with an appetite suppressant that wouldn't have side effects. But when this drug comes out, I will not be among its first users, no matter how tempted I am. I will wait at least a year to see if it's truly safe. Even then, I always opt for the lowest possible dosage of any drug, because one year of public testing isn't always enough.

New Article on Acomplia.

Experimental Diet Pill Keeping Pounds Off

By MARILYNN MARCHIONE

ORLANDO, Fla. (AP) - A second study confirms that an experimental diet pill can help people lose weight and keep it off for up to two years, setting the stage for its maker to seek approval to sell it in the United States.

The drug, rimonabant, which the French company Sanofi-Aventis hopes to sell under the brand name Acomplia, trimmed nearly 16 pounds on average from people taking the optimal dose for two years, compared with 5.5 pounds for those who took dummy pills, doctors reported Tuesday at a cardiology conference.

``The majority of the weight that was lost at one year is still maintained after two years. There is only a slight increase over that second year,'' said Dr. Luc Van Gaal of University Hospital in Antwerp, Belgium, who led the company-funded study involving 1,507 severely obese people in Europe.

About two-thirds of American adults are overweight or obese; in European countries, one-third to half are. Diet drugs sold now are only for short-term use or have unpleasant side effects that make it tough to stay on them.


Acomplia works in an entirely different way, by blocking a ``pleasure center'' in the brain, leading people to eat less and acting directly on fat cells to prevent weight gain. Company studies suggest it also might help people quit smoking.


In a North American study of 3,040 obese people reported last fall, those given the higher of two doses of the drug lost about 19 pounds and kept it off for up to two years, compared with only 5 pounds for those given fake pills.


In the new study, those on the higher dose regained some weight in the second year but fared far better than those on placebo. Waistlines in the drug group were 3.4 inches smaller after one year and 3 inches after two.


The proportion of people with metabolic syndrome - a collection of unhealthy conditions such as high blood sugar and blood pressure and low amounts of ``good'' cholesterol - went from 42 percent at the start of the study to 21 percent at two years for those on the higher dose of the drug.


Dr. Sidney C. Smith, a former American Heart Association president and cardiology chief at the University of North Carolina, said this was especially important, since 47 million Americans have metabolic syndrome.


However, the drug has side effects: 13.7 percent on the optimal dose reported nausea compared with 5.5 percent taking dummy pills, though researchers said it tended to be mild and short-lived. Rates of dizziness and diarrhea were almost twice as common on the drug.


About 19 percent on the higher dose dropped out of the study because a problem occurred, but so did 13 percent in the placebo group. Depression was the reason for discontinuing for 2.8 percent on the higher dose of the drug and 1.6 percent in the placebo group.


Dr. Julius Gaardin, a cardiologist at Wayne State University who had no ties to the study or the company, called it and similar ones on the drug ``truly landmark studies in the field of obesity.''


He said ``the safety profile was quite good'' and obesity is such a serious problem that there ought to be higher tolerability of side effects than for drugs for other conditions.


Company officials say they are on track to seek Food and Drug Administration approval within a few months.


Dr. Elizabeth Nabel, director of the National Heart, Lung and Blood Institute, said health officials would welcome an effective obesity drug if it proved safe.


``The important message is that we want men and women to focus on heart-healthy behaviors, modifications in lifestyles that promote health,'' she said.


Smith said the drug could give people ``a wonderful jump start,'' but that for long-term success, ``there have got to be some improved behavioral and diet changes going on beyond taking a pill.''

Well, since it is estimated that 1,000 people die each year from aspirin, I guess you *could* be right in saying "all drugs are poison". BUT on the other hand...what about lives that were prolonged or SAVED due to modern medicine? Saying "All drugs are poison" is throwing the baby out with the bathwater - really no different than saying "all carbs are bad" or whatever.

As far as studies go - Acomplia has already undergone two 2-year studies - in North America and Europe - and the results (as Michelle posted) look very promising indeed.

And as far as the comparison to Vioxx and other drugs that have been withdrawn from the market - I would presume that this would cause Sanofi to be even MORE diligent in ensuring that Acomplia, or any other new drug, is tested as rigorously as possible prior to its submission for FDA approval.

Incidentally...for those of you who wish to keep track of what's happening with Acomplia - there is a website called The Acomplia Report (produced by MedicalWeek - not by Sanofi) which has been tracking the progress of the drug and is regularly updated. ;)

I wholeheartedly agree with that MrsJim. I know a lot of people raised a fuss when vioxx was taken off the market, I for one was one of the people it helped and I have no ill side-effects from it. Same goes for weightloss prescriptions, a lot of people don't agree with it being used especially because it causes harm to SOME people.

As many of you know I have taken Meridia for a number of months now and have no side effects whatsoever.

Anyway on to my point, I think that to some degree the prescription drug companies are responsible for doing more than adequate research to alert us as to who can or cannot take specific drugs. There are drugs that help many people but in some instances it can kill another person.

So to kind of sum it up, what works for one may not work for another. As MrsJim said look at all the deaths from aspirin but it's still sitting on the shelf, should we yank that too? I'm willing to bet that every drug OTC or RX on the market today has caused the death of some person somewhere. Not every situation is the same and sometimes there isn't going to be a common link that we can associate, but that is where our duty as consumers comes in. Amidst all the rhetoric and fallacy and small print there are answers, and when people decided (along with their doctors) to take these medications they also agreed that they read and understand the package inserts.

I of course am not a medical or scientific professional so this is all my opinion. But I do know that everytime a doctor prescribes a med for me it is my right to decline to take it.

Hi Michelle:\

I've heard that Merck? will be bringing Vioxx back on market....but I don't know details, I either read it somewhere or heard a blurb on the news that was playing in the background noise. I would think it would be a slightly different configuration (safer)

for general information:

I ran into the pharmaceutical rep. today.....asked her about Acomplia....she believes it should be on the market in the first quarter of 2006. Also told me that the majority of patients in the clinical trials were women.

Ohhh thanks for the information marble!! I'm hoping I'm at goal by that time so I won't get to try it but I am anxious to hear about the results of other people who are going to take it once it's released.

(isn't Marbleflys the most ridicules on-screen name....my daughter was in junior high at the time i registered in 1999 and I listened to her......).

I was plaguing the rep. with questions about Acomplia.....(we've known each other for almost 6-7 years when i worked in another dept. that used her products). When i was speaking about my stubborn mid-section, she told me how most of the study patients were women who were more successful.

MrsJim..You are right. More and more insurance companies are refusing to cover the cost of surgery because they feel that it is up to us to take control over what goes in our mouth and do all we can to prevent the the surgery from taking place.

I know a lady whose husband works with mine. The surgery nearly killed her last year. YOu always hear about the ones who had a successful recovery, you do not hear about the ones who died or almost died from the surgery.

I am on xenical right now. It is a slow process but I am losing. Maybe not as fast as someone on the other drugs but still a loss. Will I take this drug if it comes out? I don't know. Perhaps not right off the bat but maybe later.

I think they will eventually come up with a drug that will fight obesity. I just don't know when.

I was on redux about three months when it was taken off. It was helping me but look at what it was doing to others.

I wish people would not try and condemn those of us who do take the pills. We all have to do this our own way, whichever way works best for us. :)

Speaking for myself, as I said previously...one of the bonuses IMO of Acomplia - IF it actually works in practice and IF it is approved by the FDA - would be its anticipated effect on the big scam market - you know, all those 'diet pills' that are sold online or in the backs of magazines or in infomercials and are asked about here SO often at Buyer Beware - the vast majority are a total waste of money and/or are VASTLY overpriced for what little they actually DO.

If there's a safe and effective pill that doctors (and I'm not talking about those weight-loss-clinic type of doctors, I'm referring to your PCP) feel comfortable prescribing to their patients on a regular basis (my own PCP will NOT prescribe diet pills except as an ABSOLUTE last resort at this point), then I predict and HOPE that the pill scam marketers will fade away. It really angers me to see how they keep taking innocent people for a ride...and I want that to STOP.

I also agree that there is no miracle cure, but they are not claiming that this pill is a cure. If you read the articles, the patients in the studies reduced their daily caloric intake by 600 calories. They aren't claiming that if you take the pill and don't make any other lifestyle changes that you will magically lose weight. Since the premise of this pill is that is helps to control cravings and such, health benefits probably occured because those on the pill were more likely to reach for fruit or vegetables or other healthy snacks and meals rather than chocolate, ice cream, greasy pizza, or any of the other things we eat that are bad for us, yet we submit to the cravings.

I guess what I'm getting at is that, no, there is no magical pill to make us all skinny, but this isn't claiming to do that anyway. I'll probably never take it simply because I don't like taking pills (I have to pretty much be on my death bed to pop a Tylenol or Sudafed).

As for FDA approval, you would think that they need to study these things more thoroughly because of what has happened in the past, but look at artificial sweeteners. How many huge issues did we have in the past with artificial sweeteners causing problems, and yet Splenda is out there, FDA-approved, and is now being found to cause health problems for some people? As much as I would like to believe that the FDA is there for our protection, I more-realistically believe that they are moving things more quickly through than they should due to corporate pressures to expedite revenues.
I wasn't a science major or a medical student or anything like that. I was a Business student, so feel free to take this expression of my opinions with a grain of salt :)

Jill - I think you're exactly right about Acomplia - it's not being purported as a magic pill - just a possible aid. Ultimately it is up to the individual to adopt and maintain healthy permanent lifestyle changes to lose and keep weight off! :)

I don't know if I should even go into the artificial sweetener debate. Splenda, asparatame and saccharin have been studied and researched for years (saccharin has actually been around for well over 100 years and has a great safety record!) and I personally believe they are safe and can be used with no problems for the vast majority of the general public. Of course there is always going to be a segment of the population who will have an adverse reaction to Splenda or asparatame, just as there are people who have adverse reactions to MSG, dairy products, wheat, peanuts, etc. I know that you've probably seen the anti-sweetener websites (one even run by the Sugar Institute - can't take the competition I guess!) but it is important to realize that the organizations behind them very much have their own agendas at play.

You can go to pubmed.com and browse through the published, peer-reviewed studies on pretty much anything...here's one abstract for example...

and some more studies can be found here...

IMO - the bottom line for any kind of drug or food or whatever comes up to this - if you don't want to use it, then you don't have to...it's a personal choice. Personally I would say that the people going after artificial sweeteners should shift their efforts towards tobacco, trans fats, and high-fructose corn syrup instead - they're FAR more harmful to the general population!

Accomplia
 

I hope its a big winner..I bought stock in the company when I read all the positive reports on it.

Slim do you know of a site to go buy stock??

Not Slim, but...the stock is traded on the NYSE. (NYSE listing code is SNY)

Their investor relations page is here ==> http://www.sanofi-synthelabo.us/index.html

You could probably buy the stock from etrade.com (this is NOT an endorsement - I've never done business with them myself) or any broker or firm licensed/registered with the SEC.

http://www.sec.gov/investor/brokers.htm

I saw a presentation about rimonabant (Acompli) at the ICRS conference last year. My husband researches similar drugs but not for a pharmaceutical company, he's in acedemics. It seems that the drug really is safe and really does make you lose weight but the bad news is that it will probably only work while you 're taking it, so after you stop, you'll gain the weight back. Also there is serious speculation that one if the reasons it works is because it makes you nauseous and therefore you don't eat. It had a hogh drop out weight at the higher dose because of this. This didn't happen at the lower dose but it did cause weight loss either. The good news is that it has open the door for other cannabinoid researched to work on other drugs that work on the same principles and that work is very promising. I really think that it will be this line of research that will create a drug that will help.

yep... pop a pill and... woooolaaaaaa a size 2...:)

Wand...we have an account with fidelitymagellen so we buy stocks there. Its gone up $5 per share since we bought it. I had this feeling about RetinA years ago but never bought it and it went nuts..hope this product prooves to be a safe and effective method for weight loss.

Here's an article from the LA Times that was published June 1st...

Still no "Magic Bullet" weight loss drug

Snippets from the above article pertaining to Acomplia:

and

(this is a really interesting article BTW!)

Fair enough. But that is why they compare it to a placebo, to factor out the effects of the subconscious mind on weight loss. Those who got accomplia got the results of placebo plus a chemical, those on placebo just got the results of their subconscious.

I think this drug is overhyped. 5% of bodyweight in a year is not a major change, for a 200 pound man that is one pound a month of weight loss. The anti-smoking effects and the fact that this will help smokers quit (since weight gain is one of the reasons given as to why people don't want to quit smoking) are far more important in my view.

Looks like FDA approval is coming closer...

Drug firms eye fat profits from new obesity pills

Plus two more down the pipeline. Interesting!

Great....something to come on the market, everyone will sing the praises of the "wonderdrug", after a while, some will start to have problems, lawsuits will fly around, people will point the finger and lay blame, and then it will be pulled off the market. Blah blah blah....same old story over and over again and people don't learn. It's sad. There will never be a "safe" drug to treat obesity. It's just not worth the risk.

i am curious
 

I wonder if this is wellbutrin/zyban remarketed?

I say that because, last time I was on wellbutrin I heard it was going to be remarkted as a weight loss drug and a stop smoking pill, mainly because they realized it was one of the very few anti depressants that didnt seem to cause weight gain..

If it is wellbutrin remarketed I wont be able to take it, I had a horrible..and I do mean HORRIBLE reaction to wellbutrin..but that is just my total personal body chemistry thing..

but I was just curious if this was wellbutrin remarketed..

I think it'd be great if a safe drug came out that really, really helped in the fight against obesity and focused on the whole impact of obesity and metabolic syndrome on the patients, as well as addressing the depression factor.

Somehow I just doubt it and think educating people on ways to reduce all the negative consequences and risk factors of obesity is where the research dollars should be going.

In the time it's taken for a number of obesity pills to go through all this development rigmarole, only to be found as less exciting than promised, many overweight people have dieted and exercised their way out of the category of needing medication for the purpose.

Sorry, but as someone said up thread, it is sad that people are going to get their hopes up again when the answer is, in many cases of obesity, so simple.

It would be nice but I thought I finally read some bad stuff on it only a few weeks ago. I think people had gotten of it for whatever reason or something of that nature.

I have been waiting for this pill to become available for over 2 years now so it would help me stop smoking, 8 months ago I gave up waiting and quit all by myself. Now I have 20 lbs. to lose because I quit, but I figure if I quit smoking by myself, I can lose this weight by myself.

The upside to doing it alone, all that money you can save to buy new clothes when you do lose the weight. Do we really need to make these people richer off us?

And it says they lost 5 to 10 percent of their body weight... Let's face it; for those with serious weight problems that is a drop in the bucket!