I do think that repeated yoyo dieting, especially repeated vlcd's (very low calorie diets) can significanlty lower metabolism, but how few calories, how many diets, who it affects, and to what degree.... those answers aren't available and may never be.
The good news though, is that while there's research evidence that suggests that metabolic rate can be reduced with repeated vlcd's, there's also evidence that metabolic rate can be increased with exercise (and possibly with diet).
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