As you probably know we cannot spot reduce. What works best is to do intense cardio and lift weights and the most important is to eat clean low calorie, low fat and as unprocessed as possible....
As Ilene said, you can't target particular areas of your body to lose weight. Weight loss happens all over and where it comes off first is .. unfortunately ... not up to us! Continue to eat healthily and exercise and you will lose weight everywhere.
You can however, do exercises that build those particular muscles - things like squats, lunges, stepups ... those will help build your quads and glutes and make them stronger and more shapely as the fat melts away!
Exercise machines that target your butt and thighs?
Continue to eat healthily and exercise and you will lose weight everywhere.