11 Sucralose Side Effects

There are some sucralose side effects that may cause you to think twice about using the sweetener. Sucralose is sold as a sugar substitute known as Splenda and is 600 times sweeter than table sugar. The product Splenda contains no calories and does not cause an insulin boost. The product has even begun replacing aspartame. The FDA reviewed studies in human beings and animals and found that sucralose did not pose any carcinogenic, reproductive, or neurological risk to humans.

Sucralose is a synthetic compound, which is basically sugar that has been modified by adding chlorine atoms. Chlorine is added to many products and does not necessarily make the product dangerous. On the other hand, consuming chlorine is not advised in large amounts. This synthetic compound is created when sugar is treated with trityl chloride, acetic anhydride, hydrogen chlorine, thionyl chloride and methanol in the presence of dimethylformamide, 4-methylmorpholine, toluene, methyl isobutyl ketone, acetic acid, benzyltriethylammonium chloride and sodium methoxide, which makes it unlike anything else found in nature.

Digesting Sucralose

Once sucralose becomes ingested it goes largely unrecognized by the body as food, which is why it has no calories. Most people don’t absorb a significant amount of it in their small intestine–only 15% by most accounts. Ironically, your body will try to clean unrecognizable substances by digesting them, so it is very likely that the healthier your gastrointestinal system is the more you’ll absorb the chlorinated molecules of sucralose.

The Side Effects of Sucralose

The sweetener has been implicated as the cause of many side effects, including:

  • Skin Rashes/Flushing
  • Panic-like Agitation
  • Dizziness and Numbness
  • Diarrhea
  • Swelling
  • Muscle aches
  • Headaches
  • Intestinal cramping
  • Bladder issues
  • Stomach pain

 There have been no long-term studies of the side effects of sucralose in humans, but the Splenda manufacturer’s own short-term studies showed that very high doses of sucralose shrank thymus glands, enlarged livers, and caused kidney disorders in rodents. The doses were measured at a level far beyond what would be expected in an ordinary diet.

Splenda contains more than just sucralose when it is sold at your local stores–it’s made with dextrose, and sometimes with maltodextrin, neither of which were included in the original studies of sucralose. The evidence of side effects associated with sucralose is accumulating slowly. Most of the testing is funded by the food industry, which has an interest in the outcome. One thing is certain. Some of the chemicals that comprise this artificial sweetener are known to be hazardous.


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