This is really where your mileage may vary, because most BMR calculators for me were very wrong (even Weight Watchers was wrong, go figure!)
Most caculators told me to eat around 2400 ~ 2500 a day for "extreme" weight loss, but I recently bought a BMF that shows how many calories my body burns a day, and my BMR is ~2900 on most days. Those calculators are obviously off, and since I was adding back in a lot for exercising, it put me at a nice maintenance level.
I say that trial and error is the way to go.
Next mini goal: 290
Next major goal: 280