I can promise you, it's no Myth. I was only on the depo for maybe no more then a year, and in that, I went from 150lbs (perfect for my height) to 280. I've so many issues now because of it. I've also been off of it for four years and am still dealing with edema (water retention), calcium deficiency, worsened anxiety & depression all of which I DID not have prior to taking Depo.