I know EXACTLY what you girls mean.
The worst part being I don't wear skirts solely on the reasoning that when I wear my pants or jeans I hear the squish squish sound they make when they kiss. hehehe
Im gonna try the deodorant trick though, the days are getting way too hot for pants now.
Even at my skinniest (I had an eating disorder and went down to 98lb) my legs would still rub, its not really a question of big thighs its more of a body shape, my legs go inwards and i dont have that separation some girls have. Oh well.
Baby powder has always been my trick, but i guess I can try all of the above as well and see which one works better