i haven't really researched but i do know after losing 100 lbs (safely i believe) that that much weight loss can really rattle your cage and also can potentially aggravate any pre-existing conditions as your body is adjusting
i had an ENORMOUS shed of hair that i'm just now recovering from after a year, i pray it stays that way, LOL but all through my 40's (before the weight loss) i was predisposed to sheds/hair loss/regrowth and i suspect i have some kind of endocrine imbalance like PCOS
i also had to adjust my thyroid meds UPwards (even though i was getting smaller) as i'm hashimoto's and hypothyroid and went through a period of adjustment.
Also in the middle/end of the weight loss i lost my sex drive (i am also perimenopausal) and emotionally i was affected, i think i flat lined more (i'm bipolar) but now i think all that is starting to balance out now that i'm in maintenance. Your body is undergoing what it considers a massive change and there certainly will be disruptions.
Discuss any meds with your doctor and be aware that dosages can certainly change, make sure you're getting all your macro nutrients and enough vitamins and minerals, get your vitamin D levels checked, etc. and just be aware that yes, it is normal but also if you feel a check up is warranted by all means go to the doctor
And congrats and hang in there!