Lori, I am hypothyroid. I took Synthroid for about six months, but I changed doctors because the one I had was just so uninformed, it was driving me nuts. The new one right off changed me to a different med. I took Unithroid for a while, then he put me on Armour. The ratio of Armour's T4 to T3 was not right for me, so he put me on Unithroid again, and a special formulation of T3. Ill effects of thyroid hormones are not something I am concerned about. I am more concerned about getting ENOUGH. It is now obvious that my problem is not just hypothyroidism, but a T4 to T3 conversion problem. Most doctors would tell me it was all in my head, but my doctor, thankfully, does a full thyroid panel on me, and knows my T3 levels are not right. I take the thyroid meds, as well as 1500mg of Metformin a day. Hopefully, now that the doctor just raised both, I will be able to start losing. It is very hard for me, though. I am not going to complain here, though. I am sure everyone who has PCOS can relate....