I've lost my first 41 pounds and can finally feel a difference. My bra band was up to a 42 and tops sometimes XL, but now I'm a 36 and a M. My pants were mostly 16's, and now my pants and skirts and tops are 10's. My ankle, back, and knees no longer bother me (well, ankle a little) and I have more energy. Stairs are easier. And I don't feel so lumpy, and my face is less puffy and weird looking.
It's been six months so I've been losing the weight slowly, but if I lose another 40 in the next 6 months then I'll be back to at least 120 by end of this year. Also I started some very light exercise this week and will work my way up. Need to get into a regular exercise routine.