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Old 03-14-2008, 12:01 PM   #1
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Default Article: After the Diet: Counseling Helps Keep Pounds Off

From the New York Times, March 12, 2008 - After the Diet: Counseling Helps Keep Pounds Off.

A group of researchers at Duke University studied a group of overweight/obese adults (average weight 213 pounds) who lost an average of 18.9 pounds over a six-month period. After the intial weight loss, the group was divided into three:

Some used an Internet-based weight counseling tool, while others had regular personal contact with a weight-loss counselor. A third group received basic instruction on maintaining weight loss, and those dieters attempted to keep the weight off on their own.
The results?

More than two years later, most everyone had gained back some of their weight. The people who tried to maintain their weight on their own fared the worst, gaining back an average of 12.1 pounds. People who used the Web-based tool gained back 11.5 pounds. However, those people who took part in the personal contact group gained back the least — regaining 8.8 pounds.
The article doesn't address the point that even the group with the best maintenance gained back an average of almost half the weight lost. Of course, this is all based on averages, not individuals, so we don't know how many successfully kept off all the weight originally lost and how many regained it all.

The original study can be found here: Comparison of Strategies for Sustaining Weight Loss (link no longer available for free )The study adds the fact that after thirty months, 71% of the study participants kept some portion of the lost weight off, which means that 39% gained it all back.
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Old 03-14-2008, 05:21 PM   #2
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Originally Posted by Meg View Post
The study adds the fact that after thirty months, 71% of the study participants kept some portion of the lost weight off, which means that 39% gained it all back.
One might argue that 71% of the people in this study have therefore had some measure of success, by medical standards if not cultural ones, and I find that to be a very happy thing indeed.

Long enough have you dream'd contemptible dreams,
Now I wash the gum from your eyes,
You must habit yourself to the dazzle of the light and of every moment of your life.
-from Song of Myself, Walt Whitman
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Old 03-27-2008, 05:55 PM   #3
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Meg -

You always find the most interesting articles. I tried to go to the original text, and it would cost me $15 to access the article. Your quotes were very revealing, however. From my perspective, though, I'm not sure how applicable these are to me. (Maybe I just choose to hope that they're not all that applicable.) I would be very interested to learn stats about people who have committed to the weight loss process long enough to lose 50 - 100 pounds, especially those that made it all the way to goal. And to be honest, if I get down to 140 pounds and find that it's too difficult to maintain at that weight, I would be comfortable gaining back up to 150 or so and maintaining there. That would mean I regained 10 pounds. Where would that categorize me? Surely I couldn't be considered a failure at that point.

These studies are very interesting for what they can tell us about what we can do to try and maintain what we've worked so hard to achieve.
onederland in 2016
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Old 03-27-2008, 06:06 PM   #4
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Rats! The current issue must be the only one available for free public viewing. Next time I'll know to copy and save.

I'll delete the link. Sorry!
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Old 03-29-2008, 04:46 PM   #5
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Vol. 299 No. 10, March 12, 2008 TABLE OF CONTENTS
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Comparison of Strategies for Sustaining Weight Loss

The Weight Loss Maintenance Randomized Controlled Trial

Laura P. Svetkey, MD; Victor J. Stevens, PhD; Phillip J. Brantley, PhD; Lawrence J. Appel, MD; Jack F. Hollis, PhD; Catherine M. Loria, PhD; William M. Vollmer, PhD; Christina M. Gullion, PhD; Kristine Funk; Patti Smith; Carmen Samuel-Hodge, PhD; Valerie Myers, PhD; Lillian F. Lien, MD; Daniel Laferriere; Betty Kennedy, PhD; Gerald J. Jerome, PhD; Fran Heinith; David W. Harsha, PhD; Pamela Evans; Thomas P. Erlinger, MD; Arline T. Dalcin; Janelle Coughlin, PhD; Jeanne Charleston; Catherine M. Champagne, PhD; Alan Bauck; Jamy D. Ard, MD; Kathleen Aicher; for the Weight Loss Maintenance Collaborative Research Group

JAMA. 2008;299(10):1139-1148.


Context Behavioral weight loss interventions achieve short-term success, but re-gain is common.

Objective To compare 2 weight loss maintenance interventions with a self-directed control group.

Design, Setting, and Participants Two-phase trial in which 1032 overweight or obese adults (38% African American, 63% women) with hypertension, dyslipidemia, or both who had lost at least 4 kg during a 6-month weight loss program (phase 1) were randomized to a weight-loss maintenance intervention (phase 2). Enrollment at 4 academic centers occurred August 2003-July 2004 and randomization, February-December 2004. Data collection was completed in June 2007.

Interventions After the phase 1 weight-loss program, participants were randomized to one of the following groups for 30 months: monthly personal contact, unlimited access to an interactive technology–based intervention, or self-directed control.

Main Outcome Changes in weight from randomization.

Results Mean entry weight was 96.7 kg. During the initial 6-month program, mean weight loss was 8.5 kg. After randomization, weight regain occurred. Participants in the personal-contact group regained less weight (4.0 kg) than those in the self-directed group (5.5 kg; mean difference at 30 months, –1.5 kg; 95% confidence interval [CI], –2.4 to –0.6 kg; P = .001). At 30 months, weight regain did not differ between the interactive technology–based (5.2 kg) and self-directed groups (5.5 kg; mean difference –0.3 kg; 95% CI, –1.2 to 0.6 kg; P = .51); however, weight regain was lower in the interactive technology–based than in the self-directed group at 18 months (mean difference, –1.1 kg; 95% CI, –1.9 to –0.4 kg; P = .003) and at 24 months (mean difference, –0.9 kg; 95% CI, –1.7 to –0.02 kg; P = .04). At 30 months, the difference between the personal-contact and interactive technology–based group was –1.2 kg (95% CI –2.1 to –0.3; P = .008). Effects did not differ significantly by sex, race, age, and body mass index subgroups. Overall, 71% of study participants remained below entry weight.

Conclusions The majority of individuals who successfully completed an initial behavioral weight loss program maintained a weight below their initial level. Monthly brief personal contact provided modest benefit in sustaining weight loss, whereas an interactive techonology–based intervention provided early but transient benefit.

Trial Registration clinicaltrials.gov Identifier: NCT00054925


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• Introduction
• Methods
• Results
• Comment
• Author information
• References

Nearly two-thirds of US adults are overweight or obese.1 Together overweight and obesity are the second leading cause of preventable death, primarily through effects on cardiovascular disease (CVD) risk factors (hypertension, dyslipidemia, and type 2 diabetes).2 Weight loss improves these risk factors, and evidence suggests that benefits persist as long as weight loss is maintained.3-8 Relatively short-term (ie, 4-6 months) behavioral interventions for adults result in clinically significant weight loss, but regain is an intractable problem.9-11 Given the vast scope of the overweight and obesity epidemic, there is a critical need for practical, affordable, and scalable intervention strategies that effectively maintain weight loss. Such strategies may also play an important role in preventing weight gain among normal-weight individuals, thereby reducing the incidence of overweight and obesity.12

Despite the potential for health benefits of weight loss maintenance, there is little evidence, particularly from clinical trials, on how to accomplish this objective. Observational studies suggest that continued intervention contacts9, 13; self-monitoring of dietary intake, physical activity, and weight14-16; accountability10, 14; and regular physical activity17 lead to sustained weight loss. However, very few trials have explicitly tested alternative strategies to sustain weight loss, and few weight loss studies have implemented interventions for longer than 18 months.13-14,18-20

Although effective weight management is an important goal for everyone, it is especially important for segments of the population at highest risk for future CVD. Minority populations in general and African Americans in particular are affected disproportionately by the obesity epidemic, with greater prevalence and incidence of overweight and obesity and greater severity of obesity-related CVD risk factors.21-23 For individuals with known CVD risk factors, weight management is a priority because of the beneficial effect of weight loss on blood pressure, lipid profile, and insulin resistance. Even though African Americans and individuals with CVD risk factors may benefit the most from effective weight loss maintenance strategies, large weight loss trials historically have had limited inclusion of minorities and other high-risk groups, thereby limiting generalizability.

In this context, we report the main results of the Weight Loss Maintenance (WLM) trial, a controlled trial of 2 practical strategies for maintaining weight loss for 30 months following initial weight loss in a large, diverse, adult population at high risk for CVD.


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Participants were enrolled in 2 phases of the clinical trial: phase 1 was a 6-month nonrandomized initial weight loss intervention for all participants; phase 2 was a randomized 30-month trial comparing 2 weight-maintenance strategies (personal contact and interactive technology) vs a self-directed control condition.

Participating institutions included 4 clinical centers—Duke University, Johns Hopkins University, Pennington Biomedical Research Center, and the Kaiser Permanente Center for Health Research. The study was approved by an institutional review board at each participating site and by a protocol review committee appointed by the National Heart, Lung, and Blood Institute. All participants provided written informed consent, and a data and safety monitoring board provided trial oversight. A detailed description of trial methods is available at http://www.kpchr.org/wlmpublic.24-25


To be included into phase 1 of the study, participants were required to have a body mass index (BMI), calculated as weight in kilograms divided by height in meters squared, of between 25 and 45; to be taking medication for hypertension, dyslipidemia, or both; to have no active CVD (those with a positive Rose angina questionnaire or a CVD event no less than 12 months before study entry and a negative stress test result could join the study with permission from their physician); access to a telephone and to the Internet; and to keep a food diary for 5 days during the screening.

Major exclusion criteria for phase 1 were medication-treated diabetes mellitus, a recent cardiovascular event or other medical or psychiatric conditions that would preclude full participation in the study, weight loss of more than 9 kg in the last 3 months, recent use of weight loss medications, or prior weight loss surgery. The primary criterion for randomization into the study's second phase was weight loss of at least 4 kg during the first phase.

Recognizing that weight loss studies often lack large numbers of male participants, we sought to enroll 40% men. In addition, a major trial goal was to recruit a study population that was approximately 40% African American. Participants self-identified their race categories.

Participant Flow

Recruitment relied on mass mailings, posted flyers, radio advertisements, and print media. Individuals meeting prescreening criteria attended a series of screening visits, after which eligible participants began the 6-month group-based, phase 1 behavioral weight-loss program, for which enrollment occurred from August 2003 through July 2004. Those who completed phase 1 and met criteria for phase 2 were randomized from February through December 2004 to one of the 3 interventions. Data collection was completed in June 2007.

Randomization assignments were stratified by clinic, race (ie, African American or non–African American), and amount of weight loss during phase 1 and were allocated in blocks of varying sizes to provide a balance in treatment assignments over time. The actual allocation assignments were generated using a password-restricted, Web-based application developed by the coordinating center and were accessible only to authorized unblinded personnel.


Data collection visits occurred at study entry and at the end of phase 1 (ie, at randomization, also referred to as baseline) and every 6 months after randomization for 30 months (21/2 years). Measurements were obtained by trained, certified staff members who were masked to treatment assignment.

Weight was measured in duplicate with the participant wearing light indoor clothes without shoes and using a high-quality, calibrated digital scale. At baseline and at 12 and 30 months after randomization, weight was measured on 2 separate days, and values were averaged. At other times, weight was measured at a single clinic visit. Height was measured once at entry using a calibrated, wall-mounted stadiometer.

Dietary intake and physical activity were measured at entry, randomization, and the 12- and 30-month follow-up visits. Diet was assessed by the Block food frequency questionnaire.26 Physical activity was measured by accelerometry. Participants were asked to wear a calibrated, triaxial accelerometer (RT3, Stayhealthy Inc, Monrovia, California) for at least 10 hours per day for at least 4 days, including 1 weekend day. Accelerometry results that comprised at least 1 weekday and 1 weekend day were used to estimate total weekly minutes of moderate to vigorous physical activity (MVPA). Total MVPA reflects both leisure time exercise and daily activity patterns (such as climbing stairs) and thus provides a measure of total MVPA-related energy expenditure.

Initial Weight Loss Intervention

The phase 1 intervention was a group-based behavioral intervention. A trained interventionist led 20 weekly group sessions over approximately 6 months. Intervention goals were for participants to reach 180 minutes per week of moderate physical activity (typically walking); reduce caloric intake; adopt the Dietary Approaches to Stop Hypertension dietary pattern, which has been shown to reduce CVD risk factors27-32; and lose approximately 1 to 2 lb per week. Participants were taught to keep food and physical activity self-monitoring records and to calculate caloric intake.

Maintenance Interventions

Participants included in the study's second phase were randomly assigned to 1 of 3 groups: a self-directed comparison condition in which participants received minimal intervention, an interactive technology–based intervention in which participants were encouraged to regularly log on to an interactive Web site; and a personal-contact intervention in which participants had monthly individual contact with an interventionist. The goals of the interactive technology–based and personal-contact interventions were maintenance of the phase 1 weight loss or loss of additional weight if desired, continued adherence to the recommended dietary pattern, and increasing moderate physical activity to at least 225 minutes per week.33-34

Both personal-contact and interactive technology–based interventions reinforced the key theoretical constructs (motivation, support, problem solving, and relapse prevention) that had been incorporated in phase 1. In addition, both active interventions incorporated features found to be associated with maintenance of behavior change in previous studies, such as continual intervention contacts, self-monitoring, accountability, prolonged continuous contact, and motivational interviewing. The counseling strategies and dietary and physical activity recommendations were the same in the personal-contact and interactive technology–based groups. Both maintenance interventions were designed to be easily disseminated and practical to implement.

At randomization, participants in the self-directed group received printed lifestyle guidelines with diet and physical activity recommendations, and they met briefly with a study interventionist again after the 12-month data collection visit.

The interactive technology–based intervention included unlimited access to a Web site designed to support weight loss maintenance.25 Interactive features allowed participants to set personal goals and action plans for the next week and to graph personal data over time. Modules addressed problem solving and motivation, and a bulletin board facilitated social support but did not provide in-person counseling.

When participants logged on, they were required to enter their current weight and were encouraged to use the Web site for self-monitoring of physical activity and caloric intake. Participants were encouraged to log on at least once a week. If they missed a self-scheduled contact, they were sent an e-mail reminder that was repeated after another week of no contact. If there was no response to 2 e-mail prompts, participants received 2 weekly automated telephone calls. If there was no subsequent log-on, study staff contacted the participant and encouraged him/her to return to the Web site.

The personal-contact intervention consisted of a case management approach with monthly person-to-person guidance and support. Participants had telephone contact with an interventionist for 5 to 15 minutes each month, except for every 4th month when they had a 45- to 60-minute individual face-to-face contact. This frequency of contact was based on previous trials9-10,35 and on disease management programs36 and is consistent with recommendations of the Medicare Medical Nutrition Therapy Amendment Act of 2001.37 The personal-contact intervention did not involve Internet contacts.

Each personal-contact session began with a self-reported weight (or measured weight at face-to-face contacts) and a review of progress since the last contact, including number of days on which a food diary was kept, frequency of weighing, average number of minutes of exercise, and progress on additional goals and action plans. Each contact provided support from the interventionist, accountability for commitments made at the previous contact, and opportunities to discuss the individual's barriers to weight loss maintenance and plans to overcome those barriers.


The primary outcome was change in weight from randomization (the start of phase 2) to the end of the study, 30 months after randomization. We also present data on the change in weight from entry (the start of phase 1) to the end of the study, as well as dichotomous measures of weight change: maintenance of at least a 4-kg weight loss relative to entry weight, no net weight gain from entry, at least 5% loss from entry, and no more than a 3% gain from randomization. Additional outcomes were total energy intake (kcal/d) and MVPA (min/wk).

Statistical Methods

The primary between-group comparisons in weight change after randomization were adjusted for entry weight, change in weight during phase 1, age, sex, race, a race x sex interaction, and clinical center (site). Each active-treatment was compared with the self-directed control condition. To correct for multiple comparisons and thereby preserve the experiment-wide type I error rate at .05 for the 2 tests in the primary outcome analysis, the smaller of these 2 P values was evaluated against an {alpha} level of .025, and, if significant, the larger P value was evaluated against an {alpha} level of .05.38-40 The question of whether weight change differed between personal-contact and interactive technology–based groups was tested (at the .05 level, in a similarly adjusted model) only if 1 of the 2 primary contrasts was significant.

The model for the secondary outcome of change in weight from entry (ie, from the start of phase 1 to the end of the study) was similar, but did not include change in weight during phase 1 as a covariate. The analyses of change in total energy intake and MVPA paralleled those for the primary outcome analysis, except that they adjusted for entry-level and phase 1 change of the outcome of interest (energy intake or MVPA) rather than weight. To preserve power for secondary outcomes, the protocol stipulated a priori that no multiple comparisons correction would be made for these analyses. We also used similar models to test for interactions with prespecified subgroups. In the case of race-sex subgroups, clinical interest in these subgroups led to an analysis of treatment effects separately in each stratum despite the absence of significant interaction.

We used multiple imputation41-42 to replace missing end-of-study weights (for 68 individuals), missing interim weights, and other measures. Only weights missing due to participant death (n = 3) were not imputed. Consequently, all 1029 randomized participants who survived are included in the primary outcome analysis. To derive imputed end-of-study weights, we used interim weights and variables related to phase 1 weight loss to estimate the parameters of a multivariate distribution from which imputed values were drawn, creating 5 separate imputation samples. Results presented herein are the average of separate, identical analyses performed on each of these 5 complete data sets, with appropriate adjustment of standard errors43 to incorporate the added variability over imputations. Hence, the standard errors are somewhat inflated relative to what would be observed using only a single-imputation sample.

The originally anticipated phase 2 sample size of 800 was designed to provide 90% power to detect a 2.0-kg difference in weight change between either of the active interventions (personal contact or interactive technology) vs the self-directed strategy and 80% power to detect treatment differences of about 2.9 kg in an expected subset of 320 African Americans. All analyses were conducted using SAS, version 9.1 (SAS Institute Inc, Cary, North Carolina), and all P values are 2 sided.


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• Introduction
• Methods
• Results
• Comment
• Author information
• References

A total of 1685 individuals participated in phase 1, the initial weight loss intervention, of whom 1032 (61%) met phase 2 entry criteria (Figure 1). Table 1 shows that 63% of those randomized were women and 38%, African American, with a mean age of 55.6 years (range, 28-83 years) and a mean initial weight loss of 8.5 kg (range, 4.0-30.3 kg).

Figure 1
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Figure 1. Flow Chart of Enrollment, Randomization, and Follow-up

aMedications included antipsychotic agents and those that treat diabetes and overweight and obesity.
bOutcome data imputed for participants with missed visit; therefore, excluding 3 deaths, all 1029 randomized participants are included in this analysis.

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Table 1. Characteristics of Participants Randomized to Phase 2a

Follow-up rates were 93% to 96% at each major data collection visit (Figure 1). There were no notable differences in participant characteristics at entry into the study between those who completed the final data-collection visit and the 68 individuals who did not (data not shown). Three participants (1 in each treatment group) died after randomization and are not included in the intention-to-treat analysis, which is therefore based on 1029 participants.

Participants in the interactive technology group logged onto the Web site an average of once a week and had at least 1 Web site contact for 77% of the months of the maintenance phase. Participants in the personal-contact group completed an average of 91% of monthly intervention contacts.

Change in Energy Intake and Expenditure

Self-reported energy intake decreased by approximately 325 kcal/d during phase 1 but increased slightly but not significantly during phase 2: 88 kcal/d in the self-directed group, 16 kcal/d in the interactive technology–based group, and 55 kcal/d in the personal-contact group. At the end of follow-up, caloric intake remained lower than entry levels by 231, 326, and 272 kcal/d, respectively. Changes in energy intake did not differ significantly between treatment groups: –33 kcal/d (95% confidence interval [CI], –117 to 51 kcal/d) for the personal-contact vs the self-directed, –72 kcal/d (95% CI, –168 to 24 kcal/d) for the interactive technology vs the self-directed, and 39 kcal/d (95% CI, –45 to 123 kcal/d) for the personal-contact vs the interactive technology groups.

During phase 1, participants increased their MVPA by about 48 minutes, but that decreased significantly in all 3 groups after randomization to the maintenance phase of the study by 32 minutes in the self-directed, 35 minutes in the interactive technology, and 33 in the personal-contact groups. By the end of follow-up, participants' exercise levels were not significantly higher than the amount of time they exercised at study entry. Changes in MVPA in phase 2 did not differ significantly between groups: –5 min/wk (95% CI, –24 to 14 min/wk) for personal-contact vs self-directed, –8 min/wk (95% CI, –27 to 12 min/wk) for the interactive technology–based vs the self-directed group, and 4 min/wk (95% CI, –11 to 18 min/wk) for the personal-contact vs the interactive technology–based groups).

Weight Outcomes

All groups regained weight after randomization by a mean of 5.5 kg in the self-directed, 5.2 kg in the interactive technology–based, and 4.0 kg in the personal-contact group (Figure 2, Table 2). However, the mean weight at 30 months remained lower in each group than mean weight at entry into the study (Figure 2, Table 2). As shown in Table 3, at 30 months after randomization on average, those in the personal-contact group regained 1.5 kg less weight than those in the self-directed group (95% CI, 2.4-0.6 kg; P = .001), whereas those in the interactive technology–based group regained only 0.3 kg less than those in the self-directed group (95% CI, 1.2-0.6 kg; P = .51). Those in the personal-contact group regained a mean of 1.2 kg less than those in the interactive technology–based group (95% CI, 2.1-0.3 kg; P = .008). As expected, the pattern of results is similar when the outcome is expressed as percentage weight change (personal-contact vs self-directed group difference, –1.8%; P < .001; interactive technology–based vs self-directed group difference, –0.4%; P = .5; personal-contact vs interactive technology–based group difference,–1.5%; P = .003, data not shown).

Figure 2
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Figure 2. Adjusted Weight Change by Treatment Group

Error bars indicate 95% confidence intervals.

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Table 2. Adjusted Weight Change at 30 Months by Treatment Group (N = 1029)a

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Table 3. Between Group Difference in Weight Change From Randomization, Over Time in Phase 2a

Additional analyses reported in Table 3 demonstrate that participants in both the interactive technology–based and personal-contact groups experienced significantly less weight regain than those in the self-directed group at each follow-up visit for 24 months following randomization.

At the end of follow-up, there were no significant interactions with baseline BMI, age, or race. Nevertheless, given the strong clinical and public health interest in the impact of obesity in African Americans, we report weight changes in race-sex subgroups. Table 4 shows that the magnitude of the observed treatment effects was generally consistent across these groups; in the absence of significant interaction, any apparent differences must be interpreted cautiously.

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Table 4. Adjusted Weight Change at 30 Months Within Race-Sex Subgroupsa

Post hoc sensitivity analyses removing 2 outliers (a participant in the interactive technology–based group who lost 30 kg and a participant in the self-directed group who gained 60 kg in phase 2) did not substantively change the results. Even without these outliers (both of whom were verified) the range of weight change after randomization was large in each group (self-directed range, –12 to 26 kg; interactive technology–based range, –12 to 24 kg; and personal-contact range, –17 to 25 kg).

A sizeable proportion of participants in each treatment group sustained clinically significant weight loss (Table 5). Overall, 41.8% of participants maintained at least 4 kg of weight loss compared with entry weight, with no significant differences between treatment groups; 70.9% remained at or below their entry weight. The proportion maintaining this much weight loss was significantly higher in the personal-contact group than in the self-directed group (P = .003), as was the difference between the personal-contact and interactive technology–based groups (P = .03). Also, 37.1% overall remained 5% or more below entry weight. The difference between the self-directed and personal-contact groups was significant (P = .02). Finally, 31.5% regained no more than 3% higher than their randomization weight. These percentages do not differ between treatment groups.

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Table 5. Percentage of Participants Who Met Various Criteria for Weight Loss, Overall and by Treatment Group


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• Introduction
• Methods
• Results
• Comment
• Author information
• References

In this study of overweight and obese adults, who are at high risk of CVD, those who were randomly assigned to the personal-contact intervention regained significantly less weight over a 30-month period than those assigned to the self-directed and interactive technology–based interventions. The personal-contact intervention was effective across all subgroups—men and women, African Americans and non-African Americans, and younger and older adults—suggesting the potential for broad public health impact. Because most personal-contact intervention contacts consisted of monthly 10- to 15-minute telephone conversations, this is an efficient and practical mode of delivery.

Although weight regain with the personal-contact intervention was statistically less than weight regain in the self-directed control group, the mean effect was a modest 1.5 kg at the end of the study. However, even modest weight loss can improve cardiovascular risk factors.3-4,7-8,44 Each kilogram of weight loss is associated with an average decrease in systolic blood pressure of 1.0 to 2.4 mm Hg44 and a reduction in incident diabetes of 16%.45 Nevertheless, it is clear that preventing weight regain is extremely challenging. In fact, some observers have asserted that long-term success rates are so low that providing long-term behavioral weight loss treatments may ultimately be futile.46-47 However, our results suggest that clinically relevant weight loss maintenance is feasible. At the end of the study, more than 45% of those in the personal-contact intervention were still maintaining at least 4 kg of weight loss, an amount with clear clinical benefits.

Our study results compare favorably with previous trials, including Trials of Hypertension Prevention Phase II (TOHP-II)7 and STOP Regain.18 In TOHP-II, an intensive behavioral weight loss intervention was followed by less intensive intervention for a total of 3 years. Only 43% of study participants lost 4 kg or more during the initial intervention compared with more than 60% in our study. Among TOHP-II participants who lost at least 4 kg in the first 6 months of intervention, their mean change in weight at 3 years was –2.3 kg7 (Nancy Cook, ScD, TOHP Coordinating Center, written communication, November 19, 2007) compared with –4.2 kg in the WLM personal-contact group.

In STOP Regain, 319 adults who reported losing at least 10% of body weight within the previous 2 years were randomly assigned to one of three 18-month maintenance interventions: face-to-face contact, Internet intervention, and control.18 Despite substantial study differences that might favor weight-loss maintenance (including shorter duration of maintenance intervention, more tailored intervention, and minimal enrollment of minorities), STOP Regain's findings were similar to those of our study: there was a 2.5-kg weight regain at 18 months in the STOP Regain face-to-face intervention compared with a 3.1-kg regain in the personal-contact intervention of WLM.

An important key to progress in combating the obesity epidemic is the extent to which effective intervention can be widely disseminated. In this regard, interactive technology–based interventions remain promising because of their potential for low-cost dissemination and the extent to which technology is rapidly becoming integrated into communication, learning, and health care. The effect of the WLM interactive technology–based intervention and the STOP Regain Internet intervention were similar: there was no significant difference in long-term regain between the Internet intervention and the control group. At 18 months, participants in the WLM Internet-based group had regained 3.8 kg compared with 4.7 kg in the STOP-Regain Internet group.18 However, in the WLM interactive technology–based group, weight regain was significantly less than in the self-directed group through 24 months of follow-up. Participants in the interactive technology–based intervention remained engaged with the Web site, continuing to log-on at least once a week throughout the study, and a large proportion maintained clinically significant weight loss. Given the potential for widespread dissemination at relatively low cost per participant, continued development of interactive technology–based intervention should be a high priority for obesity research.

For both the personal-contact and interactive technology–based interventions, future studies must determine how these maintenance interventions can be improved. It is possible that greater effects may be achieved by providing more tailored intervention. For example, individuals may benefit from different levels of intervention intensity at different times. The personal-contact approach may be superior for some individuals and the interactive technology–based approach for others, or combining elements from both interventions may have additive effects. In addition people attempting to maintain weight loss over the long-term may need to be reenergized, motivation may need to be re-engaged, and social support may need to be re-invigorated. In the interactive technology–based intervention, participants may also need technological enhancements and additional media resources, and they may need occasional personal contacts. Further development of these interventions is needed to increase the proportion of initial weight loss that is maintained and the duration over which it is maintained.

Future intervention development should also consider the fact that weight loss maintenance occurred in a substantial proportion of those in the control group. Similar effects have been seen in control groups in other lifestyle trials,48 and may simply reflect the fact that the study population is highly selected, highly motivated, and successfully lost weight in phase 1. In addition, there may be an intervention effect associated with the semi-annual data collection visits. However, beyond these factors, identification of predictors of successful weight loss maintenance, regardless of randomized treatment group, may reveal factors that can be emphasized or added to future interventions to improve long-term weight loss maintenance.

The effect of both the personal-contact and interactive technology–based interventions was modest. Future consideration of implementation of these interventions must take into account the cost relative to benefit. But it is important to recognize that to date, there has been little research specifically addressing strategies for maintenance of weight loss, despite the fact that maintenance is the main impediment to long-term weight control. Clearly, these treatment modalities are at the early stages of development. The results of our study lay the groundwork for the development of even more effective approaches to combating and reversing the obesity epidemic, and the results represent significant forward progress.

There were several limitations of the WLM study. First, only individuals who had successfully lost weight in phase 1 were randomized into phase 2. The consequence of this design feature is that the results can only be generalized to the population of successful weight losers. However, this feature was the intent of the study: to compare strategies for maintaining weight loss. Second, there were very few Hispanic participants, another group disproportionately affected by the obesity epidemic. Third, our dietary and physical activity measures may not accurately reflect energy intake and expenditure. Food frequency questionnaires tend to underestimate caloric intake49 while accelerometers may underestimate or overestimate energy expenditure, depending on the kind of physical activity.50 More accurate measurements are necessary to determine the relative contribution of changes in energy intake and expenditure to weight loss maintenance. Fourth, the duration of intervention was only 3 years. The National Heart, Lung, and Blood Institute has recommended that truly long-term benefit be assessed over at least 5 years.51 Few previous trials have continued intervention beyond 18 months,7, 18, 48 but even longer trials are needed. Fifth, the outcome of WLM was weight loss maintenance, not CVD events. The number of participants and time that would be required for a true outcome study preclude such a design, but improvement in CVD risk factors with weight loss can be reasonably expected to reduce CVD risk.

To our knowledge, this is the longest, largest randomized controlled study that specifically tested alternative strategies for maintenance of weight loss. An important feature of the WLM study was the unusually high proportion of African American participants (38% in WLM vs 18% in TOHP-II52 and 4% in STOP-Regain [Rena Wing, MD, Brown University Medical Center, written communication, February 2, 2008]). Previous trials suggest that weight loss in African Americans may be particularly challenging.7, 53-55 African Americans in our study achieved more weight loss than in other large studies,7, 55 and there were no significant race-sex interactions with treatment effects. In addition, the rates of adherence and follow-up were high, with 94% of participants attending the final data collection visit. These factors as well as the evaluation of participants prior to initial weight loss and the standardized initial weight loss intervention contribute to the strength of the study.

In conclusion, the majority of individuals who successfully completed an initial 6-month behavioral weight loss program maintained weight below their entry level after 30 additional months. Monthly brief personal-contact sessions provided modest benefit in sustaining weight loss, whereas an Internet-based intervention provided early but transient benefit. Future research should focus on longer intervention and follow-up, understanding predictors of successful maintenance and further refinement of both personal-contact and interactive technology–based interventions.


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Corresponding Author: Laura P. Svetkey, MD, Duke Hypertension Center, Box 3075, Duke University Medical Center, Durham, NC 27710 ([email protected]).

Author Contributions: Dr Svetkey had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Svetkey, Stevens, Brantley, Appel, Loria, Vollmer, Gullion, Funk, Laferriere, Kennedy, Heinith, Harsha, Evans, Erlinger, Champagne, Ard.

Acquisition of data: Svetkey, Stevens, Brantley, Appel, Hollis, Smith, Samuel-Hodge, Myers, Lien, Laferriere, Jerome, Erlinger, Coughlin, Charleston, Champagne, Bauck, Ard, Aicher.

Analysis and interpretation of data: Svetkey, Stevens, Brantley, Appel, Hollis, Loria, Vollmer, Gullion, Lien, Erlinger, Dalcin, Bauck, Ard.

Drafting of the manuscript: Svetkey, Stevens, Brantley, Appel, Hollis, Loria, Vollmer, Gullion, Funk, Ard.

Critical revision of the manuscript for important intellectual content: Svetkey, Stevens, Brantley, Appel, Hollis, Loria, Vollmer, Gullion, Funk, Samuel-Hodge, Myers, Lien, Laferriere, Kennedy, Jerome, Heinith, Evans, Erlinger, Dalcin, Coughlin, Champagne, Bauck, Ard, Aicher.

Statistical analysis: Hollis, Vollmer, Gullion, Bauck.

Obtained funding: Svetkey, Stevens, Brantley, Appel, Hollis, Loria, Vollmer, Heinith, Harsha.

Administrative, technical, or material support: Svetkey, Stevens, Brantley, Appel, Hollis, Loria, Funk, Myers, Laferriere, Jerome, Heinith, Harsha, Evans, Erlinger, Coughlin, Bauck, Ard, Aicher.

Study supervision: Svetkey, Stevens, Brantley, Appel, Hollis, Funk, Samuel-Hodge, Lien, Heinith.

Financial Disclosures: None reported.

Funding/Support: This study was supported by grants 5-U01 HL68734, 5-U01 HL68676, 5-U01 HL68790, 5-U01 HL68920, and 5-HL68955 from the National Heart, Lung, Blood Institute. Some salary support for most individuals listed above was provided by the sponsor through the grants supporting this research, or, in the case of NHLBI project office, directly from the sponsor.

Role of the Sponsor: The study sponsor participated in most aspects of the design and conduct of the trial and preparation of the manuscript.

Additional Contributions: We wish to thank the WLM Data and Safety Monitoring Board and special thanks go to the WLM participants that made this study possible. In addition, we would thank the following individuals at each of the participating sites who made substantial contributions to the work but who are not authors: Joel Bronstein, Blondeaner Brown, William Fan, MD, Jeanne Gresko, Tovon Hamilton, Aidan Hysjulien, Keely Kelly, Martis King, Velda Martin, Heather McGuire, MD, Tonya Milligan, LaVerne Pruden, LaChanda Reams, Patrice Reams, Fran Rukenbrod, RD, LDN, Sonia Steele, MPH, RD, LDN, and Edward Van Williamson, Duke University Medical Center, Durham, North Carolina; Andrea Booth, Cassie Brode, BA, Berkley C. Curtis, Jr, MS, PA-S, Maura K. Deeley, Debra J. Gayles, BS, Tara Harrison, Gloria Lawrence, Adriana E. Matos, BA, Karen McCully, MSc, LDN, Denise Monnett, Dana Owens, BS, Theresa L. Panichello, Mark E. Poisall, MS, CSCS, Ryan Rinker, Joy Q. Saunders, Amber C. Summers, MHS, RD, and Karen White MS, RD, Johns Hopkins Pro Health, Baltimore, Maryland; Kristina Booker, BS, Leah Brooks, Adrianne C. Feldstein, MD, MS, Craig Fleming, MD, Renee Giroux, RD, LD, CDE, Cheryl A. Johnson, Ed M, Thomas Knapp, Ann MacFarlane, Leah Puderbaugh, Debbie Reck, Jodi Reed, Kathy Schwab, MPH, RD, Nina Scott, LSWC, Dana R. Sturtevant, MS, RD, Marti Summer Judy Wick, RN, MAT, Catherine Willeford, MS, RD, and Carol L. Young, DTR, Kaiser Permanente Center for Health Research Clinical Site, Portland, Oregon; Calynn Bunol, Lindsay Coates, Laura Decuir, RD, LDN, Frank Greenway, MD, Katherine Lastor, LDN, RD, Lekeisha Lee, Erma Levy, MPH, RD, LDN, Jennifer Perault, Dawn Rachal, Anne Schulte, Liz Tucker, and Dana Vieselmeyer, Pennington Biomedical Research Center, Baton Rouge, Louisiana; Michael Allison, BS, Chuhe Chen, PhD, Luanna Diller, Judy Donald, MS, BSN, Clifton Hindmarsh, MS, Njeri Karanja, PhD, RD, Nidhi Kochar, MS, Teresa Kimes, MS, Carrie Meeks, Richard Meenan, PhD, Parker Pettus, MS, Rina Prasad, BA, PgDipLGA, and Gayle Meltesen, MS, Coordinating Center at Kaiser Permanente Center for Health Research, Portland, Oregon; and Susan M. Czajkowski, PhD, Jungnam Joo, PhD, Eva Obarzanek, PhD, MPH, RD, Charlotte Pratt, PhD, RD, NHLBI Project Office, Bethesda, Maryland. All were compensated as a regular part of their duties.

Author Affiliations: Divisions of Nephrology (Dr Svetkey and Ms Aicher) and Endocrinology (Dr Lien), Department of Medicine, Duke Hypertension Center and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina; Health Sciences Programs, the Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon (Drs Stevens, Hollis, Vollmer, and Guillion, Mss Funk, Heinith, and Evans, and Messrs Laferriere and Bauck); Behavioral Medicine Laboratory (Drs Brantley and Myers and Ms Smith), Dietary Assessment and Food Analysis Core (Dr Kennedy), Chronic Disease Epidemiology and Health Delivery (Dr Harsha), and Nutritional Epidemiology and Dietary Assessment and Counseling (Dr Champagne), Pennington Biomedical Research Center, Baton Rouge, Louisiana; the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University School of Medicine, Johns Hopkins University, ProHealth, Baltimore, Maryland (Drs Appel, Jerome, and Coughlin and Mss Dalcin and Charleston); Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland (Dr Loria); Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill (Dr Samuel-Hodge); Department of Medicine, University of Texas Medical Branch, Austin (Dr Erlinger); and Department of Nutrition Sciences, University of Alabama at Birmingham (Dr Ard).


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This Week in JAMA
JAMA. 2008;299(10):1105.


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Strategies to Maintain Weight Loss
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