Several years ago, I was having chronic neck pain after a car accident, and my doc put me on zoloft to help with the pain. It worked very well ( I still have a happy memory of my first pain free hour, 2 days after taking it for the first time) and I was able to become pain free.
With the chronic pain I was also had a bad temper, and was miserable.
It really helped my mood too. I did have some trouble sleeping, and had some jitters, but tried taking it in the morning and that was better.
After a couple of months, I realized I had lost weight. I wasn't really struggling with my weight at the time, ( I was about 150 lbs, a bit overweight, but I wasn't worried about it) and got down to 140 in 2 months without trying. It also had the pleasant side effect of mild urinary retention, and since I had a mild incontinence issue,
I was perfectly happy with that.
I gained the weight back slowly after weaning off. The incontinence returned.
3 years ago I started to have problems with depression. I tried the zoloft again, and the effects were not the same. It made me sleepy, no jitters, and no effects on weight. Also, I had had surgery for the incontinence, and wound up getting repeated bladder infections because of the urinary retention.
Effexor was the same.
I am now on wellbutrin, since the urinary effects are minimal, but I am not sure of the effects on my depression, (my temper is flaring a lot these days too) or appetite or libido.