Levothyroxine should be taken first thing in the morning with just a small glass of water, then you should not eat anything for an hour. It is easiest to put it by your bed along with some water and just set your alarm a little early. If you do go on metformin then that should be taken with your meals during the day for maximum effectivness. I take both and would not give up either. When taking thyroid medicine, no matter which kind it takes a while to build up in your body so you will not get the total effect for about 6 weeks. You may not notice that it is working because of the gradual buildup, but one day you will wake up and think "Hey I feel the best I have in years" That is when it is fully working. You may also have to have some adjustments to your thyroid meds too.
For the PCOS, metformin is a wonder drug and I have been taking it for many years ( 14 to 15) and will never give it up.
I hope this is the answers you are looking for, let me know if you have anymore questions.
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