I'm afraid that you're looking for a magic pill that probably just doesn't exist.
I surely wish there was one myself, as I could really use some magic way to help me lose this weight, but so far, what I've found is that you have to modify your eating and exercising habits, and you have to do it permanently. That's the only way I know to lose weight permanently.
I took phen-fen, and lost 60 pounds. Thankfully, I didn't have any permanent heart damage, but I've long since gained back that 60 pounds plus 25 more, some of which I've now lost again.
I'm currently doing the Weight Watchers online program, and I really like it. When it doesn't work (and I don't lose weight), I can usually attribute it to my not working the program carefully enough. Right now, though, I've been stuck at the same weight for weeks. I'm going to increase my exercise, and I bet it comes off soon! Knee pain be damned, I am going to get some exercise!