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Old 08-14-2013, 04:44 PM   #7
Senior Member
Join Date: Oct 2012
Posts: 430

S/C/G: 211/159/140

Height: 5'4"


If you have not already done so, it might be time to see an endocrinologist. Have you tested adrenal hormones, thyroids (the whole panel) and sex hormones (estrogen/progesterone, testosterone)? In particular, cortisol should be monitored over a 24 hr period. I am not sure whether you take the pill, otherwise a very low dose estrogen may be helpful. Particularly if your sleep patterns vary with your cycle.

Have you tried to take melatonin (this may be your circadian rhythm tablets)? Usually sleep requires the production of melatonin and decreases in the levels of serotonin in the brain (it is actually a bit more complicated). Serotonin production in the brain requires uptake of the amino acid tryptophan. Since you seem to eat meat mainly in the evening, you may get your tryptophan up. Cheese and some fruit are also high in tryptophan. In the morning, melatonin goes down again and serotonin up. So, maybe eat trp-rich foods in the morning. A long shot, but nevertheless.

You may also be on the right track experimenting with carbs. Maybe try to see what the effects of a ketogenic diet (50g carbs/day) are versus a high carb diet. Your epilepsy drugs may have gone in the direction of ketogenic diet. Low carb dieting will adjust your insulin and leptin levels. If doing a ketogenic diet, make sure your thyroids are fine.

Otherwise investigate magnesium levels, L-carnitine, omega-3 (fish!) etc. to see whether you have some deficiency.

I have found that lack of sleep/disrupted circadian rhythm induces low-level chronic inflammation, which leads to weight gain. You eventually get into a vicious cycle where one feeds the other. Your brain will have altered metabolism when sleep patterns are disrupted long-term. Also, many hormones, including active T3 thyroid hormone, follow a circadian rhythm. So does leptin.

Circadian rhythm:

There is definitely a link between glucose (carbs) and sleep via small peptides called orexins. Sleep/wakefulness comes in because narcoleptics seem to have orexin-deficiency. Narcolepsy has also been linked to obesity, probably also due to orexin.
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