I just turned 44 last week. I honestly haven't noticed any "life" changes. I still feel and look the way I did in my 20's.
I think you meant "peri-menopausal" and I don't think that usually starts til around 50...
The only difference I noticed was at age 35...I think I was more...mmmm...how should I say...firey
Fine wine...better with time.
Oh and...to add to Bargoo
's comment, you are NOT OVERWEIGHT by any chart.