I cannot give you any specific answer, but I would assume that there would be at least a subtle difference - and sometimes those subtle differences can feel really big!.
My gym recently up-graded about 80% of their weight machines. I very quickly found out that although the major group muscles for each machine were being used in basically the same way, there were all of these little muscles near them that weren't being used so much in the old machines but were in the new (or maybe were being used in a slightly different way). While using the machines, all I could tell was that the exercises "felt different" it wasn't until later that night that I came to realize the full brunt of that difference. OUCH!
I'd suggest approaching the machine like it is completely new to you, pull back on the intensity a bit and work your way back up. Those little muscles in your legs will thank you.