I think it's different for every one. My enormous behind, boobs and hips went away - which I always thought was familial, but apparently when I got slim enough - it wasn't.
But my calves and cankles - no.
.
But they are better (lots)! And I feel so fabulous overall that I hardly ever think about them. I still get to wear fabulous (tiny) clothing.
And thankfully having cankles doesn't cause diabetes, cancer or heart disease!